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Duloxetine is indicated for the treatment of chemotherapy-induced neuropathic pain in adults. It is also indicated for anxiety, depression, and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults, but not in pediatrics or pediatric oncology patients. We present the case of a 10-year-old child with acute lymphoblastic leukemia, who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and comorbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.
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http://dx.doi.org/10.1089/jpm.2021.0526 | DOI Listing |
Genet Med
September 2025
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK. Electronic address:
Purpose: Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is a rare cancer susceptibility syndrome exclusively attributable to pathogenic variants in FH (HGNC:3700). This paper quantitatively weights the phenotypic context (PP4/PS4) of such very rare variants in FH.
Methods: We collated clinical diagnostic testing data on germline FH variants from 387 individuals with HLRCC and 1,780 individuals with renal cancer, and compared the frequency of 'very rare' variants in each phenotypic cohort against 562,295 population controls.
Multimed Man Cardiothorac Surg
September 2025
Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Kawasaki, Japan.
Kommerell's diverticulum (KD) combined with a right-sided aortic arch (RAA) and an aberrant left subclavian artery (ALSA) is a rare congenital vascular anomaly causing significant compressive dysphagia. Treatment options, including open surgery, thoracic endovascular aortic repair and hybrid approaches, are debated due to anatomical complexities. We report a 48-year-old female with dysphagia from symptomatic KD, RAA and ALSA, clearly delineated by preoperative computed tomography angiography.
View Article and Find Full Text PDFNat Plants
September 2025
College of Horticulture, Northwest A&F University, Yangling, Shaanxi, China.
Acetophenones, which show scattered distribution across phylogenetically distant plants and fungi, play diverse roles in plant-plant, plant-insect, plant-microbiome and even animal-insect interactions. However, the enzymatic basis of acetophenone biosynthesis in plants remains unknown. Here we elucidate the complete biosynthetic pathway of picein (4-hydroxyacetophenone glucoside) from 4-coumaroyl-CoA using pear (Pyrus) as a study system.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Mining and Materials Engineering, McGill University, 3610 Rue University, Montreal, Quebec, Canada H3A 0C5.
As the first-line chemotherapeutic for glioblastoma multiforme (GBM), Temozolomide (TMZ) suffers from rapid degradation in physiological fluid, making it difficult to deliver sufficient doses of active TMZ to GBM tumors without inducing severe side effects. By protecting TMZ and then controlling its release using an external stimulus, we can prevent its premature degradation, thereby increasing its active concentration at the tumor site. Here, we present a near-infrared (NIR) controlled system in which TMZ is protected within a polymer before its on-demand release.
View Article and Find Full Text PDFUgeskr Laeger
August 2025
Hæmatologisk Afdeling, Sjællands Universitetshospital, Roskilde.
Multiple myeloma (MM) is a rare disease with approximately 400 new cases per year in Denmark. Involvement of the central nervous system (CNS) is only seen in around 1% of all MM cases (MM-CNS). Knowledge about MM-CNS is therefore extremely limited and diagnosing the condition is often challenging, due to heterogeneous presentations which can be confounded by neurological symptoms caused by the typical features of MM or common treatment side effects.
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