Hyponatremia with Antidepressant: A Rare Side Effect from Duloxetine in a Child with Acute Leukemia.

J Palliat Med

Division of Cancer Medicine, Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Published: December 2022


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Duloxetine is indicated for the treatment of chemotherapy-induced neuropathic pain in adults. It is also indicated for anxiety, depression, and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults, but not in pediatrics or pediatric oncology patients. We present the case of a 10-year-old child with acute lymphoblastic leukemia, who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and comorbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.

Download full-text PDF

Source
http://dx.doi.org/10.1089/jpm.2021.0526DOI Listing

Publication Analysis

Top Keywords

rare side
12
side duloxetine
8
child acute
8
chemotherapy-induced neuropathic
8
neuropathic pain
8
duloxetine
6
hyponatremia antidepressant
4
antidepressant rare
4
duloxetine child
4
acute leukemia
4

Similar Publications

Purpose: Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is a rare cancer susceptibility syndrome exclusively attributable to pathogenic variants in FH (HGNC:3700). This paper quantitatively weights the phenotypic context (PP4/PS4) of such very rare variants in FH.

Methods: We collated clinical diagnostic testing data on germline FH variants from 387 individuals with HLRCC and 1,780 individuals with renal cancer, and compared the frequency of 'very rare' variants in each phenotypic cohort against 562,295 population controls.

View Article and Find Full Text PDF

Kommerell's diverticulum (KD) combined with a right-sided aortic arch (RAA) and an aberrant left subclavian artery (ALSA) is a rare congenital vascular anomaly causing significant compressive dysphagia. Treatment options, including open surgery, thoracic endovascular aortic repair and hybrid approaches, are debated due to anatomical complexities. We report a 48-year-old female with dysphagia from symptomatic KD, RAA and ALSA, clearly delineated by preoperative computed tomography angiography.

View Article and Find Full Text PDF

Acetophenones, which show scattered distribution across phylogenetically distant plants and fungi, play diverse roles in plant-plant, plant-insect, plant-microbiome and even animal-insect interactions. However, the enzymatic basis of acetophenone biosynthesis in plants remains unknown. Here we elucidate the complete biosynthetic pathway of picein (4-hydroxyacetophenone glucoside) from 4-coumaroyl-CoA using pear (Pyrus) as a study system.

View Article and Find Full Text PDF

As the first-line chemotherapeutic for glioblastoma multiforme (GBM), Temozolomide (TMZ) suffers from rapid degradation in physiological fluid, making it difficult to deliver sufficient doses of active TMZ to GBM tumors without inducing severe side effects. By protecting TMZ and then controlling its release using an external stimulus, we can prevent its premature degradation, thereby increasing its active concentration at the tumor site. Here, we present a near-infrared (NIR) controlled system in which TMZ is protected within a polymer before its on-demand release.

View Article and Find Full Text PDF

Multiple myeloma (MM) is a rare disease with approximately 400 new cases per year in Denmark. Involvement of the central nervous system (CNS) is only seen in around 1% of all MM cases (MM-CNS). Knowledge about MM-CNS is therefore extremely limited and diagnosing the condition is often challenging, due to heterogeneous presentations which can be confounded by neurological symptoms caused by the typical features of MM or common treatment side effects.

View Article and Find Full Text PDF