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Understanding the genetic underpinnings of schistosome host preferences is critical. Luo et al. recently identified genes associated with intermediate and definitive host-switching based on a new chromosome-level genome for Schistosoma japonicum, population genetic comparisons, and follow-up experiments. This represents a guide to fully map-selected schistosome genes using population genetics.
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http://dx.doi.org/10.1016/j.pt.2022.04.005 | DOI Listing |
Front Cell Infect Microbiol
September 2025
Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, China.
Introduction: , a zoonotic parasitic disease, induces complex immune regulation during infection. The inflammatory responses and immunosuppressive mechanisms co-exist to maintain immune homeostasis in schistosomiasis. B7-H4 is a critical immune checkpoint molecule that modulates T cell activation and exerts immunosuppressive effects.
View Article and Find Full Text PDFCommun Biol
August 2025
Section of Structural and Synthetic Biology, Department of Infectious Disease, Imperial College London, London, UK.
The neglected tropical disease schistosomiasis continues to be a global health concern, especially in low- and middle-income countries, with at least 250 million people infected worldwide and a further 779 million at risk of infection. Schistosoma japonicum, which is found in parts of South Asia, causes intestinal schistosomiasis in humans, as well as infecting up to forty other mammalian species. Therefore, novel diagnostics that can detect S.
View Article and Find Full Text PDFPathogens
August 2025
Division of Research Capacity Development, South African Medical Research Council (SAMRC), Tygerberg, Cape Town 7505, South Africa.
The immunological interactions between soil-transmitted helminths (STHs) and herpes simplex virus type 2 (HSV-2), particularly in the context of co-infection, are poorly understood. Next-generation sequencing (NGS) offers a powerful approach to explore these complex immune responses and uncover potential therapeutic targets. This study leveraged NGS and bioinformatic tools to investigate transcriptional changes and immunological pathways in female genital tract (FGT) tissues of BALB/c mice acutely infected with (), HSV-2, or co-infected.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Schistosomes are parasitic flatworms that infect more than 200 million people globally. However, there is a shortage of molecular tools that enable the discovery of potential drug targets within schistosomes. Thus, praziquantel has remained the frontline treatment for schistosomiasis despite known liabilities.
View Article and Find Full Text PDFG3 (Bethesda)
August 2025
Department of Biology and Center for Genomics & Systems Biology, New York University, New York, New York 10012, USA.
Outbreeding populations harbor large numbers of recessive deleterious alleles that reduce the fitness of inbred individuals, and this inbreeding depression potentially shapes the evolution of mating systems, acting as a counterweight to the inherent selective advantage of self-fertilization. The population biological factors that influence inbreeding depression are numerous and often difficult to disentangle. We investigated the utility of obligately-outcrossing Caenorhabditis nematodes as models for inbreeding depression.
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