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Background And Objectives: Atrial tachycardias (ATs) from noncoronary aortic cusp (NCC) uncovered after radiofrequency ablation for atrial fibrillation (AF) are rarely reported. This study was conducted to investigate the prevalence and clinical characteristics of NCC ATs detected during AF ablation and compare their characteristics with de novo NCC ATs without AF.
Methods: Consecutive patients who underwent radiofrequency catheter ablation for AF were reviewed from the multicenter AF ablation registry of 11 tertiary hospitals. The clinical and electrophysiological characteristics of NCC AT newly detected during AF ablation were compared with its comparators (de novo NCC AT ablation cases without AF).
Results: Among 10,178 AF cases, including 1,301 redo ablation cases, 8 (0.08%) NCC AT cases were discovered after pulmonary vein isolation (PVI; 0.07% in first ablation and 0.15% in redo ablation cases). All ATs were reproducibly inducible spontaneously or with programmed atrial stimulation without isoproterenol infusion. The P-wave morphological features of tachycardia were variable depending on the case, and most cases exhibited 1:1 atrioventricular conduction. AF recurrence rate after PVI and NCC AT successful ablation was 12.5% (1 of 8). Tachycardia cycle length was shorter than that of 17 de novo ATs from NCC (303 versus 378, p=0.012). No AV block occurred during and after successful AT ablation.
Conclusions: Uncommon NCC ATs (0.08% in AF ablation cases) uncovered after PVI, showing different characteristics compared to de-novo NCC ATs, should be suspected irrespective of P-wave morphologies when AT shows broad propagation from the anterior interatrial septum.
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http://dx.doi.org/10.4070/kcj.2021.0388 | DOI Listing |
JACC Clin Electrophysiol
August 2025
Department of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia; The Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, Australia. Electronic address:
Background: Focal atrial tachycardia (AT) may arise from a range of closely related anatomical sites in the paraseptal region.
Objectives: This study sought to define the anatomical distribution and examine the electrocardiographic and electrophysiological features of paraseptal focal AT, suggest a mapping approach, and report ablation outcomes.
Methods: This retrospective single-center study defined paraseptal ATs as originating from the following anatomical sites: right perinodal region, septal tricuspid annulus, right septum, coronary sinus (CS) ostium, left septum, septal mitral annulus, aorto-mitral continuity, and non-coronary cusp (NCC) adjacent.
Ultrasound Med Biol
October 2024
State Key Laboratory of Power Transmission Equipment Technology, School of Electrical Engineering, Chongqing University, Chongqing, China.
Viruses
September 2022
Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.
Selective gene delivery to a cell type of interest utilizing targeted lentiviral vectors (LVs) is an efficient and safe strategy for cell and gene therapy applications, including chimeric antigen receptor (CAR)-T cell therapy. LVs pseudotyped with measles virus envelope proteins (MV-LVs) have been retargeted by ablating binding to natural receptors while fusing to a single-chain antibody specific for the antigen of choice. However, the broad application of MV-LVs is hampered by the laborious LV engineering required for every new target.
View Article and Find Full Text PDFKorean Circ J
July 2022
Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Heart Rhythm
May 2022
Department of Cardiology, Cardiovascular Center, Shin-Koga Hospital, Kurume City, Fukuoka, Japan.
Background: The efficacy of catheter ablation from the noncoronary aortic cusp (NCC) of verapamil-sensitive atrial tachycardia arising near the atrioventricular node (AVN-AT) has yet to be fully clarified.
Objective: We elucidated the determinant of an effective AVN-AT ablation from the NCC.
Methods: After identifying the earliest atrial activation site (EAAS) during tachycardia, the direction of the slow conduction zone (SCZ) of the reentry circuit was identified by demonstrating manifest entrainment in 26 patients with AVN-AT.