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Invited for the cover of this issue are Jeffrey Einkauf, Vyacheslav Bryantsev, Bruce Moyer, and Radu Custelcean from Oak Ridge National Laboratory. The image depicts an anion receptor functionalized with a new photoswitchable chromophore, the diiminoguanidinium group, with exceptionally strong sulfate-binding affinity that can be turned off by photoirradiation with UV light. Read the full text of the article at 10.1002/chem.202200719.
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http://dx.doi.org/10.1002/chem.202201106 | DOI Listing |
Chem Sci
August 2025
Department of Chemistry, National Taiwan University Taipei 10617 Taiwan
Chiral sterically overcrowded alkenes are potential candidates for artificial light-driven rotary molecular motors (LRMMs), which perform a full 360° unidirectional rotation around the C[double bond, length as m-dash]C bond through a series of photochemical and thermal isomerization processes. However, the majority of the reported LRMMs adopt an intrinsic chirality (, an integration of the chirality center with the photoresponsive unit), which hampers the effective gating of their rotary direction through chirality switching. Herein, we report a new sterically overcrowded alkene equipped with a boronic acid receptor for dynamic covalent bonding with chiral vicinal diols, enabling it to function as an extrinsic chirality-based LRMM.
View Article and Find Full Text PDFJ Am Chem Soc
July 2025
Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Photopharmacology offers powerful opportunities to control protein signaling using photoresponsive ligands. Despite the vast potential of photoswitchable ligands for spatiotemporal target protein control, research on ligand-protein binding kinetics of these ligands remains limited. Herein, we describe the discovery of the first radiolabeled photoswitchable ligand, [H]VUF26063 ([H]), to assess light-dependent ligand-protein binding kinetics in real time.
View Article and Find Full Text PDFJ Med Chem
June 2025
Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Clenbuterol is a potent partial agonist on the human β-adrenergic receptor (β-AR) and available for veterinary use to treat respiratory diseases. We executed an "" strategy to generate a small library of photoresponsive azobenzene derivatives of clenbuterol. Illumination with two complementary wavelengths allowed interconversion between isomeric and forms, as proven by UV/vis, NMR and LC-MS studies.
View Article and Find Full Text PDFAnal Chem
June 2025
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.
Dephosphorylation is an essential process in cellular signaling with protein phosphatases playing a critical role in cellular functions and disease mechanisms. Herein, a novel and ultrasensitive photoelectrochemical (PEC) biosensing platform for detecting protein tyrosine phosphatase 1B (PTP1B) activity was developed, based on the sensitization effect of a magnetic ZnFeO@ZrMOF nanoenzyme integrated with a two-step radical polymerization signal amplification strategy. The PTP1B-specific phosphorylated peptide (p-peptide) was immobilized on a 96-well plate and then coupled to the ZnFeO@ZrMOF nanoenzyme through coordination between its phosphate groups and Zr ions.
View Article and Find Full Text PDFACS Nano
March 2025
State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.
Solid-state nanopore and nanochannel biosensors have revolutionized protein detection by offering label-free, highly sensitive analyses. Traditional sensing systems (1st and 2nd stages) primarily focus on inner wall (IW) interactions, facing challenges such as complex preparation processes, variable protein entry angles, and conformational changes, leading to irregular detection events. To address these limitations, recent advancements (3rd stage) have shifted toward outer surface (OS) functionalization but are constrained by single-protein recognition models.
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