Total synthesis of (±)-mersicarpine following a 6- radical cyclization.

Org Biomol Chem

Department of Applied Chemistry, National Yang Ming Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan.

Published: August 2022


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Article Abstract

Described is a total synthesis of racemic mersicarpine from diethyl 4-oxopimelate. The synthetic route takes advantage of a 2-indolyl radical cyclization to construct the pyrido[1,2-]indole scaffold bearing the all-carbon quaternary stereocenter.

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http://dx.doi.org/10.1039/d2ob00620kDOI Listing

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