98%
921
2 minutes
20
Oxidative stress and obesity are critical risk factors for metabolic syndrome. The consumption of functional food ingredients can a viable strategy to alleviate oxidative stress and obesity. In this study, the hydro-ethanolic extract of the edible insect was prepared and its bioactive components were characterized. The total polyphenol contents, total flavonoid contents, antioxidant and pancreatic lipase (PL) inhibitory activities of the extract were determined . In total, 60 bioactive components were tentatively identified in the extract. Polyphenols and fatty acids were further quantified using LC-MS and GC-MS, respectively. extract possessed excellent antioxidant and PL inhibition activities. Salicylic acid, gallic acid, liquiritigenin, and naringenin, which were the major polyphenols in the extract, interacted with PL through hydrogen bonding, hydrophilic or hydrophobic and pi-cation interactions. Thus, extract can be used as a nutraceutical to alleviate oxidative stress-induced disease and manage obesity.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021923 | PMC |
http://dx.doi.org/10.3389/fnut.2022.860174 | DOI Listing |
3 Biotech
October 2025
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
This study evaluated the effect of Mogan large-leaf yellow tea (MG-LYT) on preventing obesity. It was found that cold-brewed yellow tea has stronger anti-obesity effects in high-fat diet (HFD)-induced obese mice than hot-brewed tea, due to its higher content of non-esterified catechins, as shown by metabolomic and high-performance liquid chromatography (HPLC) analysis. Notably, epigallocatechin (EGC), a key non-ester catechin, likely enhances pancreatic lipase inhibition through allosteric modulation, which explains the greater effectiveness of cold-brewed tea.
View Article and Find Full Text PDFACS Omega
August 2025
Federal University of Rio Grande do Norte, Center for Healthy Sciences, Postgraduate Nutrition Program, Natal, Rio Grande do Norte 59078-970, Brazil.
Obesity is a multifactorial disease, with numerous therapeutic targets. In this context, various peptides and proteins have been the focus of research due to their ability to influence body weight regulation. This study aimed to investigate the effect of trypsin inhibitor isolated from tamarind seeds (TTI) on lipase activity, both in vitro and in vivo, using the zebrafish () as an animal model.
View Article and Find Full Text PDFMol Nutr Food Res
August 2025
Laboratory of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Suruga Ward, Shizuoka, Japan.
Pu-erh tea attenuates obesity and lipid metabolism by inhibiting pancreatic lipase, but prior studies used doses much higher than typical human consumption, which raised concerns about renal toxicity. This study aimed to investigate the effects of human drinkable doses of Pu-erh tea extract (PTE) on obesity and lipid metabolism. High-fat diet (HFD)-fed male C57BL/6J mice were orally administered distilled water (HFD group), 107.
View Article and Find Full Text PDFPharmaceuticals (Basel)
July 2025
Postgraduate Program in Chemistry, Chemistry Institute, Universiade Federal do Mato Grosso do Sul, Campo Grande CEP 79070-900, Matogrosso do Sul, Brazil.
Diabetes and cancer are two of the most life-threatening disorders affecting individuals of all ages worldwide. This study aimed to develop a novel (bocaiuva) fruit pulp oil-loaded nanoemulsion and evaluate its inhibitory effects on α-glucosidase and pancreatic lipase, as well as its antiglycant activity and cytotoxicity against cancer cells. Additionally, this study assessed the impact of both the oil and the nanoemulsion on blood cells.
View Article and Find Full Text PDFFuture Med Chem
August 2025
Department of Chemistry, Faculty of Science, Umm Al-Qura University, Makkah, Saudi Arabia.
Aims: Tyrosinase and pancreatic lipase are key enzymes involved in melanin biosynthesis and lipid metabolism, respectively. Their inhibition offers therapeutic potential in treating hyperpigmentation and obesity. This study aimed to synthesize and evaluate a series of flavonols () as potential dual enzyme inhibitors.
View Article and Find Full Text PDF