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Complete traumatic cervical fracture-dislocation with spinal cord transection in children is a rare entity with no evidence-based guidelines on management. The authors reviewed the literature for pediatric spinal cord injury and present the case of a 3-year-old with traumatic cervical fracture-dislocation and spinal cord transection who presented as a cervical-6 complete spinal cord injury (ASIA A). His other organ systems injured included liver, spleen, bowel, and abdominal aortic injury. The patient underwent halo placement for preoperative reduction followed by open reduction and internal fixation with posterior segmental instrumented fusion. Intraoperatively, the patient had motor evoked potential signals present below the level of his injury. Early postoperative follow-up demonstrated that, although his leg function did not improve, he did demonstrate improvement in upper extremities. This is a rare case of complete cervical spinal cord transection in a pediatric patient. We elected to manage this challenging case with initial external reduction and orthosis with a halo vest followed by acute posterior cervical fusion. Despite a cervical-6 injury level on clinical exam, there was electrographic evidence of function below that level on intraoperative neuromonitoring. Postoperatively the patient has recovered some lost function.
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http://dx.doi.org/10.7759/cureus.23213 | DOI Listing |
Neurosci Bull
September 2025
Laboratory Animal Center, Fudan University, Shanghai, 200032, China.
Nr4a2 (Nurr1) is well known to be vital for midbrain dopaminergic neurons. Recent single-cell RNA analyses reveal that Nr4a2 is expressed in lateral cerebral regions, within neurons named L4/L5/L6 IT Car3. These neurons have attracted intense attention for the molecular mechanisms underlying their development and functions.
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Department of Anatomical Sciences and Cognitive Neuroscience, TMS.C., Islamic Azad University, Tehran, Iran.
Nat Cardiovasc Res
September 2025
Center for Vascular Research, Institute for Basic Science and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
The meninges, consisting of the dura, arachnoid and pia mater that surround the brain and spinal cord, have been recognized from the earliest anatomical studies. First identified in 1787, lymphatic vessels in the dura are now receiving greater attention as their contribution to cerebrospinal fluid (CSF) clearance in diverse neurological conditions is being investigated. New methods have increased the understanding of dural lymphatics, but much is still being learned about their heterogeneity, intracranial and extracranial connections, and factors that govern their functions and maintenance.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California, San Diego, La Jolla, CA, United States. Electronic address:
Nano-electronics based neural implants represent a rapidly advancing interdisciplinary domain at the intersection of bioelectronics, nanotechnology, and neuro-engineering. These implantable systems are engineered to restore, modulate, or augment neural functions by establishing high-fidelity, long-term interfaces with neural tissues. The design of such implants necessitates careful consideration of both materials and structural configurations to ensure biocompatibility, mechanical compliance, electrical functionality, and chronic stability.
View Article and Find Full Text PDFJ Neurosurg Case Lessons
September 2025
Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
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