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A study protocol for a randomized controlled feasibility trial of behavioural therapy for interepisode bipolar symptoms (STABILISE).
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Department of Public Health and Sport Sciences, University of Exeter, Exeter, UK.
Background: In between episodes of (hypo) mania and major depression, people with bipolar disorder can experience ongoing low mood or mood instability, and these may also be present as part of cyclothymic disorder. This is a phase II evaluation of an adapted form of behavioural therapy (STABILISE) for inter-episode bipolar symptoms. The study aims to establish the feasibility and acceptability of the therapy and research procedures, including an economic component, to inform a future definitive trial.
View Article and Find Full Text PDFApplication of Professional Best Practices in Postmortem Forensic Toxicology.
J Anal Toxicol
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Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1200 SW 34th Street, Gainesville, FL, 32607, United States.
Postmortem forensic toxicology plays a critical role in medicolegal death investigations through the identification and quantitation of drugs and other substances in postmortem fluids and tissues. Due to the complexity of this sub-discipline, consistent application of best practices is critical for ensuring accurate and reliable results, particularly in the context of challenges such as emerging novel psychoactive substances, complex poly-drug interactions, postmortem drug redistribution, and analytical limitations inherent with postmortem specimens. Although there has been significant progress in the development of consensus-based forensic toxicology standards, their scope is intentionally broad to accommodate human performance, postmortem, regulated and non-regulated employment drug testing, court-ordered toxicology, and other applications.
View Article and Find Full Text PDFAbstracts of papers presented at the XLIST ANNUAL SCIENTIFIC CONFERENCE OF THE PHYSIOLOGICAL SOCIETY OF NIGERIA held between 13th and 16th February 2024 at the Rivers State University, Port Harcourt, and PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria.
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Department of Prosthodontics, JSS Dental College & Hospital, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.
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Intracerebral hemorrhage following mild ARIA-H in an APOE ε2 carrier receiving lecanemab.
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Memory and Brain Wellness Center, University of Washington, Seattle, WA, USA.
Objective: Report a case of an apolipoprotein E (APOE)ε2 carrier receiving lecanemab who developed late onset intracerebral hemorrhage (ICH) following amyloid-related imaging abnormalities-hemorrhage (ARIA-H).
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