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Previous research has shown that the relationship between childhood abuse and the presence of auditory hallucinations is mediated by dissociation, specifically depersonalization and absorption. The current study assessed dissociation as a mediator of the relationship between childhood abuse and auditory hallucination and associated in those with dissociative identity disorder (DID; = 50) and schizophrenia spectrum disorders (SSD; = 49). It also tested whether dissociation mediated the relationship between childhood abuse and the of non-auditory hallucinations. Participants completed measures of childhood abuse, dissociation, auditory hallucination frequency, characteristics, distress, and non-auditory hallucinations. With distress associated with auditory hallucinations as the outcome, depersonalization was a mediator in the DID group. For non-auditory hallucinations, in the DID group depersonalization and amnesia were mediators between childhood abuse and the presence of visual, tactile and olfactory hallucinations. In the SSD group absorption mediated between childhood abuse and visual, olfactory and gustatory hallucinations. Results suggest that the presence of non-auditory hallucinations in DID and SSD are associated with different dissociative experiences.
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http://dx.doi.org/10.1080/15299732.2022.2064579 | DOI Listing |
Mol Psychiatry
September 2025
Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
Dysregulated dopaminergic signaling has been implicated in the pathophysiology of major depressive disorder (MDD) and childhood sexual abuse (CSA), but inconsistencies abound. In a multimodal PET-functional MRI study, harnessing the highly selective tracer [C]altropane, we investigated dopamine transporter availability (DAT) and resting-state functional connectivity (rsFC) within reward-related regions among 112 unmedicated individuals (MDD: n = 37, MDD/CSA: n = 18; CSA no MDD: n = 14; controls: n = 43). Striatal DAT and seed-based rsFC were assessed in the dorsal and ventral striatum and the ventral tegmental area.
View Article and Find Full Text PDFChild Abuse Negl
September 2025
University of Melbourne, School of Psychological Sciences, Parkville, Melbourne, 3010, Australia. Electronic address:
Background: Adverse childhood experiences (ACEs) are linked to poor mental health outcomes, yet much of the existing research focuses on cumulative risk rather than the impact of distinct types of adversity. This limits insights into how specific ACE patterns influence psychopathology. Additionally, inquiries into links between ACE exposure and mental health typically focus on a single symptom class, overlooking co-occurring psychopathologies.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.
Background: Maternal childhood maltreatment has been associated with higher risk of adverse neurodevelopment in offspring. Chronic systemic inflammation has been associated with childhood maltreatment and has been identified as a gestational risk factor for adverse neurodevelopment in offspring. Thus, inflammation may be a mechanism by which maternal exposure to maltreatment affects offspring neurodevelopment.
View Article and Find Full Text PDFFront Psychol
August 2025
Département de Psychologie, Université de Montréal, Montréal, QC, Canada.
Introduction: Sleep disturbances represent a major concern for many adolescents. While adolescents with a history of trauma may be particularly vulnerable to sleep disturbances, the mechanisms underlying the association between childhood sexual abuse and sleep disturbances (e.g.
View Article and Find Full Text PDFActa Psychol (Amst)
September 2025
Wannan Medical College, Wuhu, Anhui, China. Electronic address:
Background: Mental health issues among middle school students are closely associated with life events and childhood trauma experiences. However, the interactive pathways among these three factors remain unclear. Based on network analysis, this study constructs a network model to identify core nodes (high-intensity symptoms) and bridge nodes (cross-group associated symptoms), aiming to reveal their interaction mechanisms and provide a foundation for targeted interventions in adolescent mental health.
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