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Current miniaturized ultrasound transducers suffer from insufficient attenuation from the backing layer due to their limited thickness. The thickness of the backing layer is one of the critical factors determining the device size and transducer performance for miniaturized transducers inserted and operated in a limited space. Glass bubbles, polyamide resin, and tungsten powder are combined to form a new highly attenuative backing material. It has high attenuation (>160 dB/cm at 5 MHz), which is five times greater than silver-based conductive epoxy commonly used for high-frequency ultrasound transducers, appropriate acoustic impedance (4.6 MRayl), and acceptable damping capability. An intravascular ultrasound (IVUS) transducer constructed with the 170 [Formula: see text] of the proposed backing layer demonstrated that the amplitude of the signal returned from the backing layer was 1.8 times smaller, with ring-down attenuated by 6 dB. Wire-phantom imaging revealed that the axial resolution was 30% better with the suggested backing than silver-based conductive epoxy backing. Because of its excellent attenuation capability even at a limited thickness, simple manufacturing process, and easy customization capability, the suggested highly attenuative backing layer may be used for miniaturized ultrasound transducers.
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http://dx.doi.org/10.1109/TUFFC.2022.3164451 | DOI Listing |
Eur J Pharm Biopharm
September 2025
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, PR China. Electronic address:
Iguratimod (IGU) is a novel anti-rheumatic drug, which has anti-inflammatory effects, inhibits bone destruction, and promotes bone formation. However, the gastrointestinal side-effects caused by oral tablets of IGU pose a challenge. This study aimed to develop an IGU transdermal patch for Rheumatoid Arthritis (RA) through ion-pair and chemical penetrant strategies to improve the therapeutic efficacy.
View Article and Find Full Text PDFAnal Chem
September 2025
Marshall Laboratory of Biomedical Engineering, Shenzhen Key Laboratory for Nano-Biosensing Technology, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, China.
Chronic periodontitis, a frequent complication of diabetes, is exacerbated by bacterial biofilms that drive progressive periodontal tissue destruction and systemic inflammation. Conventional treatments, utilizing mechanical debridement and systemic antibiotics, often fail to eradicate bacterial biofilms, promote antibiotic resistance, and lack real-time monitoring, leading to suboptimal therapeutic outcomes. Herein, we report a separable bilayer microneedle (MN) patch that enables localized, antibiotic-free, biofilm-targeted therapy and in situ biomarker-based monitoring for the integrated management of chronic periodontitis.
View Article and Find Full Text PDFJ Nanobiotechnology
September 2025
Department of Endocrinology, Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210002, China.
Microneedle patch encapsulated with active medication holds significant potential promise in the realm of anti-obesity therapy. Nevertheless, the improvement of actives delivery efficiency remains a significant challenge. In this paper, we present novel separable cryo-microneedles patches delivered with capsaicin integrated mesoporous dopamine (mPDA) for obesity treatment through activating TRPV1 and inducing lipid droplet dissolution.
View Article and Find Full Text PDFJ Chem Educ
November 2024
Department of Chemistry, The University of Texas at San Antonio (UTSA), San Antonio, Texas 78249-0698, United States.
An outreach activity was developed and performed where familiar food items (e.g., beverages, leaves, vegetables, and citrus peels) were extracted with ethanol or ethyl acetate, and the extracts were analyzed through thin-layer chromatography (TLC).
View Article and Find Full Text PDFLangmuir
August 2025
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
Persistent overoxidation, inflammation, and bacterial infection impede diabetic wound healing. As the third biological gasotransmitter, hydrogen sulfide (HS) can modulate inflammation, mitigate oxidative stress, and facilitate angiogenesis, potentially promoting diabetic wound healing. In this study, bilayer microneedle patches (MNs) were prepared through a two-step mold-casting process using blends of poly(vinyl alcohol) and poly(vinylpyrrolidone) as substrates.
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