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http://dx.doi.org/10.1016/j.jtcvs.2022.02.036 | DOI Listing |
J Intellect Dev Disabil
September 2025
Applied Health Sciences Degree Program, Furtwangen University, Furtwangen, Germany.
Background: Few studies have examined how professional caregivers perceive the relocation of adults with intellectual and developmental disabilities from the family home to specialised residential settings.
Method: We conducted semi-structured interviews with eight professional caregivers, exploring their experiences of admitting adults with intellectual and developmental disabilities into residential care. Transcripts were analysed using Mayring's qualitative content analysis.
J Thorac Cardiovasc Surg
September 2025
Chair and Distinguished Professor of Surgery, Keck School of Medicine of The University of Southern California.
Arthroscopy
September 2025
Southern California Orthopedic Institute, Van Nuys, CA. Electronic address:
Platelet Rich Plasma (PRP) has been utilized to augment ACL surgery, with studies reaching conflicting conclusions as to the extent of beneficial effects. While the majority of ACL surgeries I have performed have not been augmented, I have utilized PRP (and bone marrow concentrate) enough to conclude that my personal experience matches literature finding no significant difference in outcomes, and, at present does not support routine augmentation of ACL reconstruction (ACLR) with PRP. Instead, I believe the "crimson duvet" effect of reaming tunnels is a key source of cells and signals that promote healing and initiate graft incorporation.
View Article and Find Full Text PDFJ Clin Epidemiol
September 2025
Australian Living Evidence Collaboration, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Objectives: Guideline developers have long recognised the importance of maintaining up-to-date guidelines to support evidence-based practice and policy, contributing to narrowing the gap between research generation and its application. This commentary reflects on key insights from the Journal of Clinical Epidemiology's Methods for Living Guidelines series and issues an open call for contributions aimed at advancing the development, implementation and evaluation of living guideline methods.
Methods: This commentary synthesises methodological innovations and practice experiences shared in the Methods for Living Guidelines series, highlighting emerging practices and lessons learned.
AAPS J
September 2025
Precision Medicine Bioanalytical & Translational Sciences, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
CAR-T-cells can drive MHC class-I-mediated CD8 + cytotoxic T-cell response towards CAR constructs in addition to an antibody response. Immune response may also develop towards residuals present in the CAR-T cell product such as AAV, CRISPR/CAS9, and expamers. Health authorities recommend developing assays to assess both humoral and cellular immunogenicity towards the CAR-T protein.
View Article and Find Full Text PDF