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Candida osteomyelitis is a rare disorder; however, its incidence has drastically risen especially during the last 3 decades. Diagnosis is usually delayed due to nonspecific symptoms. Thus, its management would not be performed at the proper time, which leads to increased morbidity. The optimal management of candida osteomyelitis is not clearly defined but most recommendations advise prolonged antifungal therapy in addition to surgery. Here, we report candida osteomyelitis in a patient with a history of pancreatic adenocarcinoma that presented with prolonged FUO as her first presentation. Fortunately, her symptoms completely resolved after prolonged medical therapy despite delay diagnosis due to her unusual presentation. To the best of our knowledge, it is the first report of candida vertebra osteomyelitis that presents with prolonged FUO as the first presentation.
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http://dx.doi.org/10.1002/ccr3.5582 | DOI Listing |
Rev Argent Microbiol
September 2025
Universidad de Buenos Aires, CONICET, Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM), Buenos Aires, Argentina. Electronic address:
Infections caused by the genus Candida have acquired considerable significance in recent years due to the enhanced susceptibility of immunocompromised hosts. There have been increasing reports of multidrug resistance (MDR) in several Candida species, posing a major hurdle to antifungal therapy. Accordingly, exploring and developing novel anti-Candida agents has become a priority.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300350, PR China. Electronic address:
Balancing antibacterial efficacy, mechanical integrity, and biocompatibility remains a critical challenge in drug release systems for wound dressings. Many antimicrobial agents exhibit inherent cytotoxicity, compromising cell viability and tissue compatibility. To address this, an Absorbable Gelatine Sponge was synthetised based on high-viscosity hydroxypropyl methylcellulose (HPMC K100M) and loaded with silver citrate nanorods (AgCit), which confine silver nanoparticles to enable controlled ion release.
View Article and Find Full Text PDFBioorg Med Chem
September 2025
Universidade Federal Fluminense, Instituto de Química, Niterói, RJ,CEP 24020-141, Brazil. Electronic address:
Invasive Candidiasis infections are a clinical challenge, with limited effective therapeutic agents and increasing resistance. The discovery of new antifungal agents is urgently required. Here, we developed a new series of 2-methyl-1,4-naphthoquinone (Menadione) Tethered to 1H-1,2,3-triazolyl-selenoester in good yields, which exhibit antifungal potential activity against Candida species.
View Article and Find Full Text PDFFront Glob Womens Health
August 2025
Department of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.
Background: Vulvovaginal Candidiasis (VVC) is a condition commonly caused by . It is the second most common infection of the female genitalia affecting many women worldwide. Studies have identified unhealthy genital care practices to be associated with the infection among women including expectant mothers.
View Article and Find Full Text PDFInt J Nanomedicine
September 2025
Department of Pharmaceutics and Pharmaceutical Technology, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia.
Background: Candidiasis, predominantly caused by , poses a significant global health challenge, especially in tropical regions. Nystatin is a potent antifungal agent that is hindered by its low solubility and permeability, limiting its clinical efficacy.
Methods: This study aimed to investigate the potential of a layer-by-layer (LBL) coating system, employing chitosan and alginate, to improve the stability, entrapment efficiency (%EE), and antifungal efficacy of nystatin-loaded liposomes against Candida albicans.