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A 19-year-old man visited our hospital because of diarrhea and blood and liver dysfunction. Magnetic and endoscopic retrograde cholangiography revealed diffuse narrowing of the common biliary tract and intrahepatic biliary tract. A biopsy specimen from the narrowed area of the common biliary tract revealed IgG4-related sclerosing cholangitis (IgG4-SC). Colonoscopy showed multiple aphthoid colitis. He was treated with corticosteroids, and the levels of hepatobiliary enzymes, IgG, and IgG4 gradually decreased. This is an extremely rare case of colitis in which the patient had a phenotype of sclerosing cholangitis similar to IgG4-SC, which was finally diagnosed as primary sclerosing cholangitis.
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http://dx.doi.org/10.1159/000521538 | DOI Listing |
Liver Int
October 2025
Hannover Medical School, Department of Diagnostic and Interventional Radiology, Hannover, Germany.
Background And Aims: We aimed to ascertain the prevalence of sarcopenia in patients with primary sclerosing cholangitis (PSC) and to assess the prognostic value as a biomarker for disease outcome.
Methods: We collected data from 224 patients (148 male, 76 female; mean age 41 years) from January 2002 to December 2021, with a confirmed diagnosis of PSC who underwent magnetic resonance imaging (MRI). Muscle mass was quantified at the level of the third lumbar vertebra by measurement of psoas muscle thickness (PMT) and total psoas muscle area (PMA).
Medicine (Baltimore)
September 2025
College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Observational studies suggest associations between elevated body mass index (BMI) and autoimmune liver diseases (AILDs), yet causal evidence remains limited. This Mendelian randomization (MR) study aimed to elucidate the causal role of BMI in AILDs and identify mediating pathways involving 91 circulating cytokines. Utilizing public genome-wide association study data, univariate and multivariate MR analyses were conducted to assess causal relationships between BMI and 3 AILDs.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Gastrointestinal Surgery, The Wujin Hospital Affiliated with Jiangsu University, Changzhou, China.
To date, evidence on the relationship between H. pylori infection and biliary diseases remains unclear. This Mendelian randomization (MR) study aim to investigate the causal relationship between H.
View Article and Find Full Text PDFUnited European Gastroenterol J
September 2025
Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital and Vita Salute San Raffaele University, Milan, Italy.
Background: Few data are available on the impact of primary sclerosing cholangitis (PSC) on inflammatory bowel disease (IBD).
Objective: We conducted a retrospective study using TriNetX to compare the outcomes of patients with IBD and those with concomitant IBD and PSC.
Methods: All patients with a confirmed diagnosis of Crohn's disease (CD), ulcerative colitis (UC), or indeterminate colitis with or without PSC were eligible.
ACG Case Rep J
October 2024
Division of Gastroenterology & Liver Diseases, Department of Medicine, University of Southern California, Los Angeles, CA.
Patients with chronic liver disease have a higher surgical risk compared with those without. For patients with inflammatory bowel disease (IBD), literature has shown that earlier surgical intervention for those with severe IBD has led to better outcomes regarding mortality and remission. For patients who have both IBD and chronic liver disease, management can be complex.
View Article and Find Full Text PDF