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The COVID-19 pandemic has proven the need for point-of-care diagnosis of respiratory diseases and microfluidic technology has risen to the occasion. Mesa Biotech (San Diego, CA) originally developed the Accula platform for the diagnosis of influenza A and B and then extended the platform to SARS-CoV-2. Mesa Biotech has experienced tremendous success, culminating in acquisition by Thermo Fisher for up to $550m USD. The Accula microfluidics platform accomplished the leap from the lab to commercial product through clever design and engineering choices. Through information obtained from interviews with key Mesa Biotech leaders and publicly-available documents, we describe the keys to Mesa's success and how they might inform other lab-on-a-chip companies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012986 | PMC |
http://dx.doi.org/10.1039/d2lc00081d | DOI Listing |
Genome Biol
July 2025
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association studies (GWAS). We construct and analyze a multi-ancestry GWAS dataset in the Alzheimer's Disease Genetics Consortium (ADGC) to test for novel shared and population-specific late-onset Alzheimer's disease (LOAD) susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6728 African American, 8899 Hispanic (HIS), and 3232 East Asian individuals, performing within ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis.
Results: We identify 13 loci with cross-population associations including known loci at/near CR1, BIN1, TREM2, CD2AP, PTK2B, CLU, SHARPIN, MS4A6A, PICALM, ABCA7, APOE, and two novel loci not previously reported at 11p12 (LRRC4C) and 12q24.
Nat Neurosci
August 2025
Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer's disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N = 12,048), including 7,394 cognitively unimpaired (CU) participants, 2,177 participants with mild cognitive impairment (MCI) and 2,477 participants with dementia.
View Article and Find Full Text PDFRespir Res
July 2025
Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Background: Pulmonary emphysema occurs frequently in older adults, often without airflow limitation. Its presence predicts symptoms, respiratory hospitalizations and deaths, and all-cause mortality. Proteomics may provide further insights into emphysema pathogenesis and inform therapeutic targets.
View Article and Find Full Text PDFERJ Open Res
May 2025
Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Background: Pulmonary microvascular dysfunction has been suggested to be an early feature of interstitial lung changes, which may precede interstitial lung disease. The prospective association of albuminuria, a marker of endothelial dysfunction, with interstitial lung abnormalities (ILA) and high-attenuation areas (HAA) remains unexplored.
Methods: The study included participants with available spot urinary albumin-creatinine ratio (UACR) and computed tomography data for ILA and HAA enrolled in two independent cohorts, Multi-Ethnic Study of Atherosclerosis (MESA; n=2248) and Age Gene/Environment Susceptibility (AGES)-Reykjavik (n=3509).
Cureus
May 2025
Medical Office, Click Therapeutics, New York, USA.
Academic medicine is at a crossroads. Amid historic federal disinvestment in research and persistent cultural resistance to industry collaboration, the traditional academic compact, based on grants, publications, and tenure, is no longer sustainable. Drawing on firsthand experience as a medical school dean, faculty, and biotech executive, this editorial argues that academic institutions must urgently reform how they value and support entrepreneurial scholarship.
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