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A lack of clinical response to empiric antimicrobials behooves the clinician to reflect further on diagnostic considerations. When prescribing antibiotics, determining the correct dose, most optimal route of administration, and considering the pharmacokinetic properties of the drug with respect to clinical and patient factors are crucial.
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http://dx.doi.org/10.1002/ccr3.5594 | DOI Listing |
Patient
September 2025
Department of Public Health, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark.
Background: Patient and public involvement (PPI) is crucial for aligning research with public needs, reducing research waste, and enhancing the relevance and quality of evidence. Evaluating PPI is necessary to ensure its effectiveness. However, despite its recognised importance, researchers have reported a lack of robust tools for evaluating PPI systematically.
View Article and Find Full Text PDFImaging Neurosci (Camb)
September 2025
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin Center for Advanced Neuroimaging, Berlin, Germany.
In multivariate pattern analysis (MVPA) for functional magnetic resonance imaging (fMRI) signals, trial-wise response amplitudes are sometimes estimated using a general linear model (GLM) with one onset regressor for each trial. When using rapid event-related designs with trials closely spaced in time, those estimates can be highly correlated due to the temporally smoothed shape of the hemodynamic response function. In previous work (Soch et al.
View Article and Find Full Text PDFSmall
September 2025
Hybrid Materials Center (HMC), Sejong University, Seoul, 05006, Republic of Korea.
2D chalcogenide-based memristors have the potential to be used in artificial biological visual systems since their synaptic behavior can be optically and electrically modulated. Furthermore, 2D van der Waals materials such as SnS can be used to integrate multifunctional optoelectronic devices by employing a rational design. Here, the simulation of a human biological visual system is reported by using multifunctional optoelectronic synaptic devices.
View Article and Find Full Text PDFMultivariate Behav Res
September 2025
SEVEN, University of Amsterdam, Amsterdam, The Netherlands.
Many psychological phenomena can be understood as arising from systems of causally connected components that evolve over time within an individual. In current empirical practice, researchers frequently study these systems by fitting statistical models to data collected at a single moment in time, that is, cross-sectional data. This raises a central question: Can cross-sectional data analysis ever yield causal insights into systems that evolve over time-and if so, under what conditions? In this paper, we address this question by introducing Equilibrium Causal Models (ECMs) to the psychological literature.
View Article and Find Full Text PDFAnnu Rev Phytopathol
September 2025
Department of Plant Pathology, The Ohio State University, Wooster, Ohio, USA; email:
The birth of modern plant disease epidemiology can be traced back to 1963, coinciding with the first international gathering of epidemiologists and the publication of Vanderplank's landmark treatise, : . Over the past six decades, the field has evolved in numerous ways, with ever-increasing use of mathematics, statistics, and computational methods, although many of the epidemiological principles expounded by Vanderplank remain valid. Two broad subdivisions can be seen in quantitative epidemiology: () theoretical and semiempirical modeling of the temporal, spatial, and spatiotemporal dynamics of disease and () prediction or forecasting of epidemics (or disease outbreaks, or the need for control interventions) on a real-time basis based on environmental (and other) data, usually using empirical models.
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