Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The brown planthopper, , is a difficult-to-control insect pest affecting rice yields in Asia. As a structural component of the inter-alpha-trypsin inhibitor (ITI), the inter-alpha-trypsin inhibitor heavy chain (ITIH) has been reported to be involved in various inflammatory or malignant disorders, ovarian development, and ovulation. To reveal the function of ITIH4 in , the gene encoding ITIH4 () was cloned and characterized. ITIH4 contains a signal peptide, a vault protein inter-alpha-trypsin domain, and a von Willebrand factor type A domain. qPCR analysis showed that was expressed at all developmental stages and in all tissues (fat body, ovary, and gut), with the highest expression in the fat body. Double stranded (ds) injection clearly led to an RNAi-mediated inhibition of the expression of and resulted in reduced survival, delayed ovarian development, and reduced egg production and egg hatching. These results indicate that plays an important role in the development and reproduction of .
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951764 | PMC |
| http://dx.doi.org/10.3390/insects13030303 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Plasma proteomics in septic shock and alcohol-related pancreatitis: a hyaluronan-centered approach.
Clin Proteomics
August 2025
Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, 75185, Uppsala, Sweden.
Background: Sepsis is a critical condition characterized by a dysregulated immune response to infection. As sepsis develops to septic shock, its most severe form, morbidity and mortality increases. Hyaluronan is a key component of the extracellular matrix and the endothelial glycocalyx.
View Article and Find Full Text PDFRemote blood sampling differential protein expression associated with persistent hypertension following a hypertensive disorder of pregnancy.
medRxiv
July 2025
Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Objective: Hypertensive disorders of pregnancy are associated with future cardiovascular risk, however, the underlying mechanisms are unclear. We sought to test the feasibility of postpartum remote blood sampling following a hypertensive disorder of pregnancy and subsequently identify differentially expressed proteins in individuals who developed hypertension.
Study Design: We used data from a randomized clinical trial evaluating the feasibility of lifestyle intervention and home blood pressure monitoring of individuals with pre-pregnancy body mass index ≥25 kg/m and new-onset hypertensive disorders of pregnancy.
Knockdown of ITIH4 reduces inflammatory damage and apoptosis of A549 cells induced by through NLRP3 inflammation.
Allergol Immunopathol (Madr)
July 2025
Department of Pediatric Internal Medicine, Huai'an Second People, s Hospital The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China.
Background: Mycoplasma pneumoniae (MP) is a leading cause of community-acquired respiratory infections in pediatric patients. This study aimed to investigate whether the pro-inflammatory function of inter-alpha-trypsin inhibitor heavy chain (ITIH4) contributes to the pathogenesis of MP-induced pneumonia.
Method: A549 cells were stimulated with MP to model pneumonia in vitro.
Pathophysiological mechanisms in severe preeclampsia: role of upregulated proteins in blood pressure, extracellular matrix and immunity.
Rev Bras Ginecol Obstet
July 2025
Universidade Estadual Paulista Instituto de Biociências de Botucatu Departamento de Biofísica e Farmacologia BotucatuSP Brasil Departamento de Biofísica e Farmacologia, Instituto de Biociências de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil.
Objective: This study aims to compare the plasma protein profiles between 7 preeclampsia patients with severe features (PE+) and 7 preeclampsia patients without severe features (PE-) and 10 healthy pregnancies (HP); identify differentially expressed proteins among these groups and explore the altered signaling pathways and their association with the severity of this cardiovascular condition.
Methods: Plasma proteins were quantified using mass spectrometry, followed by comprehensive bioinformatics and statistical analyses. Protein identification and annotation were performed using UniProt and PatternLab for Proteomics.
Properdin, transcortin and HGFAC are novel plasma biomarkers in canine chronic inflammatory enteropathies from active disease to remission.
Sci Rep
July 2025
Division of Small Animal Internal Medicine, Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinärplatz 1, Vienna, 1210, Austria.
Canine chronic inflammatory enteropathies (CCIE) is a group of intestinal inflammatory conditions causing chronic or relapsing gastrointestinal symptoms. Accurate diagnosis, treatment and monitoring remain challenging, necessitating novel diagnostic tools. This study aims to investigate the plasma proteome of ten dogs with histologically confirmed CCIE during active disease and clinical remission compared to ten healthy controls.
View Article and Find Full Text PDF