Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Osteosarcoma(OS) and Ewing's sarcoma (EWS) are the two most common primary malignant bone tumors in children. The aim of the study was to identify key genes in OS and EWS and investigate their potential pathways.
Methods: Expression profiling (GSE16088 and GSE45544) were obtained from GEO DataSets. Differentially expressed genes were identified using GEO2R and key genes involved in the occurrence of both OS and EWS were selected using venn diagram. Gene ontology and pathway enrichment analyses were performed for the ensembl. Protein-protein interaction (PPI) networks were established by STRING. Further, UCSC was used to predict the transcription factors of the cell division cycke 5-like(CDC5L) gene, and GEPIA was used to analyze the correlation between the transcription factors and the CDC5L gene.
Results: The results showed that CDC5L gene was the key gene involved in the pathogenesis of OS and EWS. The gene is mainly involved in mitosis, and is related to RNA metabolism, processing of capped intron-containing pre-mRNA, mRNA and pre-mRNA splicing.
Conclusion: CDC5L, as a key gene, plays a role in development of OS and EWS, which may be reliable targets for diagnosis and treatment of these primary malignant tumors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.12200/j.issn.1003-0034.2022.03.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative mitogenomics of the eulipotyphlan species (Mammalia, Eulipotyphla) provides novel insights into the molecular evolution of hibernation.
Mitochondrial DNA A DNA Mapp Seq Anal
September 2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China.
Hibernation is an elaborate response strategy employed by numerous mammals to survive in cold conditions that involves active suppression of metabolism. Despite the role of mitochondria as energy metabolism centers during hibernation, the adaptive and evolutionary mechanisms of mitochondrial genes in hibernating animals, like hedgehogs in eulipotyphlan species, are not yet fully understood. In this study, we sequenced and assembled mitochondrial genomes of the hibernating four-toed hedgehog () and the non-hibernating Asian house shrew ().
View Article and Find Full Text PDFUV2 and LW opsin genes mediate phototactic responses in the Asian lady beetle, Harmonia axyridis.
Insect Sci
September 2025
Hubei Key Laboratory of Resources Utilization and Sustainable Pest Management, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Phototaxis is a critical behavior in insects and is closely linked to vision and environmental adaptation. Understanding how insects perceive light and exhibit phototactic responses is crucial for assessing the ecological impact of artificial light at night. However, the molecular and neural mechanisms that regulate phototactic responses in insects remain largely unknown.
View Article and Find Full Text PDFThe Transcription Factor MYB8 Positively Regulates Flavonoid Biosynthesis of Scutellaria baicalensis in Response to Drought Stress.
Plant Cell Environ
September 2025
National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry of the Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, China.
Drought stress dynamically reprograms specialised metabolism in medicinal plants. However, the transcriptional regulatory modules governing stress-adaptive metabolite synthesis remain poorly characterised. Here, we identified SbMYB8 as a drought-responsive transcription factor showing nuclear localisation and dose-dependent induction under drought in Scutellaria baicalensis.
View Article and Find Full Text PDFExploring the Bacterial Microbiota of Seeds.
Microb Biotechnol
September 2025
Departamento de Biología Funcional, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
The seed microbiota, a still underexplored component of plant-microbe interactions, plays a pivotal role in plant development and holds significant promise for advancing sustainable agriculture. By influencing essential processes such as germination, stress tolerance, nutrient acquisition and defence, seed-associated microbes offer unique advantages beyond those of soil- or rhizosphere-associated microbiomes. Notably, they are transmitted both vertically and horizontally; however, fundamental questions remain regarding their origin, ecological dynamics and functional roles across environments.
View Article and Find Full Text PDFNature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases.
Mol Ther
September 2025
Department of Medicine, UMass Chan Medical School, Worcester, MA, USA; Department of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA, USA; Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA; Li Weibo Institute for Rare Diseases Research, UMass Chan Medic
The interleukin (IL)-1 pathway is a key mediator of inflammation and innate immune responses. Its dysregulation contributes to rheumatoid arthritis (RA) and autoinflammatory diseases (AIDs). In this study, we develop a recombinant adeno-associated virus (rAAV)-based gene therapy to deliver an inflammation-inducible, secreted human IL-1 receptor antagonist (sIL-1Ra) as a complementary approach to existing IL-1 blockers.
View Article and Find Full Text PDF