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| http://dx.doi.org/10.1111/1751-2980.13092 | DOI Listing |
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Transarterial radioembolization (TARE) is a minimally invasive treatment modality for hepatocellular carcinoma (HCC) that delivers targeted radiation via radioactive microspheres. The procedure entails selective catheterization of the hepatic artery, followed by infusion of yttrium-90-labeled microspheres directly into the arterial supply of the tumor. Several technical strategies are employed to optimize precise radiation delivery while minimizing exposure to surrounding healthy liver tissue.
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Safety and efficacy of Holmium-166 selective internal radiotherapy of primary and secondary liver cancer confirmed by real-world data.
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Radiology and Nuclear Medicine Clinic, University Hospital Basel, Basel, Switzerland.
Purpose: Holmium-166 has emerged as a promising option for selective internal radiotherapy (SIRT) for hepatic malignancies, but data on routine clinical use are lacking. The purpose of this study was to describe the safety and effectiveness of Holmium-166 SIRT in real-world practice through retrospective analysis of a multicenter registry.
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Statistics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Introduction: This literature review and exploratory network meta-analysis (NMA) aimed to compare the clinical effectiveness and tolerability of selective internal radiation therapy (SIRT) using yttrium-90 (Y-90) resin microspheres, regorafenib (REG), trifluridine-tipiracil (TFD/TPI), and best supportive care (BSC) in adult patients with chemotherapy-refractory or chemotherapy-intolerant metastatic colorectal cancer (mCRC).
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Department of Gastroenterology, Hepatology and Transplant Medicine, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Recommended treatment options for advanced-stage hepatocellular carcinoma (HCC) include systemic therapy (ST) and trans-arterial radioembolization (TARE) with Yttrium-90 (Y90). Before the approval of immune-checkpoint inhibitors, a similar safety profile was reported for TARE and ST with tyrosine kinase inhibitors (TKI). However, whole-liver treatment and underlying cirrhosis were identified as risk factors for potentially lethal radioembolization-induced liver disease (REILD).
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