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Clinical Trial Protocol for ProBio: An Outcome-adaptive and Randomised Multiarm Biomarker-driven Study in Patients with Metastatic Prostate Cancer. | LitMetric
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Clinical Trial Protocol for ProBio: An Outcome-adaptive and Randomised Multiarm Biomarker-driven Study in Patients with Metastatic Prostate Cancer.

Bram De Laere , Alessio Crippa , Andrea Discacciati , Berit Larsson , Jan Oldenburg , Ashkan Mortezavi , Piet Ost , Martin Eklund , Johan Lindberg , Henrik Grönberg ,

Eur Urol Focus

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Oncology, Capio S:t Görans Sjukhus, Stockholm, Sweden.

Published: November 2022

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Article Abstract

ProBio is an outcome-adaptive, multiarm, multiple-assignment randomised, biomarker-driven platform trial in men with metastatic castration-resistant prostate cancer. Here we describe the amended clinical protocol, focusing on expansion of the trial to include patients with de novo metastatic hormone-sensitive prostate cancer.

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 Source
http://dx.doi.org/10.1016/j.euf.2022.03.005DOI Listing

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