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A 56-year-old woman with a history of connective tissue disease developed fever, and () was detected in blood cultures. Therefore, treatment with vancomycin (VCM) was initiated. Since her blood cultures persistently detected despite peripheral intravenous catheter replacement and VCM treatment, concomitant treatment with gentamicin (GM) was started. Blood cultures then became negative. Persistent bacteremia responded to combination therapy with VCM and GM. This combination therapy may increase the risk of developing renal dysfunction, but the risk can be mitigated by appropriate therapeutic drug monitoring (TDM) and dose adjustments to achieve successful treatment.
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http://dx.doi.org/10.1155/2022/8725102 | DOI Listing |
N Z Vet J
September 2025
Diagnostics, Readiness and Surveillance, Biosecurity New Zealand, Ministry for Primary Industries, Wellington, New Zealand.
Case History: In 2023, 160/245 (65%) 2-year-old KiwiCross dairy heifers from a seasonally calving Otago herd developed severe granular vulvovaginitis after calving.
Clinical Findings: Affected heifers presented 3-12 days post-calving with tail elevation, vaginal discharge and, in most cases, vulval swelling. Heifers were afebrile although some were inappetent.
Int J Infect Dis
September 2025
SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; Department of Microbiology and Biochemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontei
Background: Mycobacterium simiae is a slow-growing environmental nontuberculous mycobacterium (NTM), commonly isolated from soil and water. M. simiae is not known to transmit zoonotically or via human-to-human contact; infection is presumed to occur through direct environmental exposure.
View Article and Find Full Text PDFTurk J Pediatr
September 2025
Department of Pediatric Hematology and Oncology, Batman Training and Research Hospital, Batman, Türkiye.
Background: Brucellosis is a zoonotic infection transmitted to humans by ingestion of contaminated unpasteurized dairy products or via direct or indirect contact with infected animals. It is characterized by nonspecific symptoms like fever and joint pain, and laboratory findings including anemia, leukopenia, thrombocytopenia, or rarely pancytopenia. Here we report a case of brucellosis with thrombocytopenia that did not improve despite anti-brucella treatment and required intravenous immunoglobulin treatment.
View Article and Find Full Text PDFCNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFArch Orthop Trauma Surg
September 2025
Adult Reconstruction and Joint Replacement Service, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA.
Background: Differentiating periprosthetic joint infections (PJI) from aseptic failure is challenging in total joint arthroplasty. To date, there is no consensus about the most accurate criteria to diagnose PJI. The current study compares common diagnostic PJI criteria.
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