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| http://dx.doi.org/10.1016/j.jbspin.2022.105378 | DOI Listing |
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Bidirectional Mendelian randomization study reveals causal relationships between polymyalgia rheumatica and serum metabolites.
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Polymyalgia rheumatica (PMR) is a prevalent chronic inflammatory disorder among the elderly, presenting diagnostic and therapeutic challenges. Existing treatments like glucocorticoids have significant side effects, and the molecular mechanisms of PMR remain unclear. This study employed a 2-sample bidirectional Mendelian randomization approach to explore the causal relationship between 1091 metabolites, 309 metabolite ratios, and PMR risk.
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Department of Surgery, Lahey Hospital & Medical Center, Burlington, Massachusetts, USA.
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Polymyalgia rheumatica (PMR) is a common inflammatory disorder in the elderly, characterized by pain and stiffness in the shoulder and pelvic girdles. The diagnosis of PMR may be challenging due to its nonspecific clinical features and overlap with other musculoskeletal conditions, such as degenerative rotator cuff tendinopathy (dRCT). Although subacromial-subdeltoid bursitis (bSAD) is included in the 2012 ACR/EULAR classification criteria for PMR, its diagnostic specificity is limited unless further ultrasound (US) parameters are considered.
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Université Paris-Saclay, UVSQ, Inserm CESP U1018, Gustave Roussy, Villejuif, France.
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