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Background: The spread of COVID-19 at the local level is significantly impacted by population mobility. The U.S. has had extremely high per capita COVID-19 case and death rates. Efficient nonpharmaceutical interventions to control the spread of COVID-19 depend on our understanding of the determinants of public mobility.
Objective: This study used publicly available Google data and machine learning to investigate population mobility across a sample of US counties. Statistical analysis was used to examine the socioeconomic, demographic, and political determinants of mobility and the corresponding patterns of per capita COVID-19 case and death rates.
Methods: Daily Google population mobility data for 1085 US counties from March 1 to December 31, 2020, were clustered based on differences in mobility patterns using K-means clustering methods. Social mobility indicators (retail, grocery and pharmacy, workplace, and residence) were compared across clusters. Statistical differences in socioeconomic, demographic, and political variables between clusters were explored to identify determinants of mobility. Clusters were matched with daily per capita COVID-19 cases and deaths.
Results: Our results grouped US counties into 4 Google mobility clusters. Clusters with more population mobility had a higher percentage of the population aged 65 years and over, a greater population share of Whites with less than high school and college education, a larger percentage of the population with less than a college education, a lower percentage of the population using public transit to work, and a smaller share of voters who voted for Clinton during the 2016 presidential election. Furthermore, clusters with greater population mobility experienced a sharp increase in per capita COVID-19 case and death rates from November to December 2020.
Conclusions: Republican-leaning counties that are characterized by certain demographic characteristics had higher increases in social mobility and ultimately experienced a more significant incidence of COVID-19 during the latter part of 2020.
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http://dx.doi.org/10.2196/31813 | DOI Listing |
Adv Ther
September 2025
Sanofi, Gentilly, France.
Introduction: No head-to-head studies comparing the efficacy of avalglucosidase alfa (AVA) with cipaglucosidase alfa + miglustat (Cipa+mig) have been conducted in patients with late-onset Pompe disease (LOPD). Two indirect treatment comparisons (ITCs) were conducted to estimate the effects of AVA versus Cipa+mig.
Methods: ITCs were conducted using simulated treatment comparisons (STCs), adjusting for differences in prognostic factors and treatment effect modifiers.
Environ Plan B Urban Anal City Sci
March 2025
Department of Landscape Architecture and Urban Planning, Texas A&M University.
Urban green space disparities persist amid rapid urbanization, widening the supply-demand gap between parks and developed area. Population density is a critical determinant in estimating park visitors, defining suitable park locations, and allocating facilities for park accessibility. Conventionally, population density data were used as a foundational basis for urban green space planning decisions, often derived from sources like the US Census Bureau, primarily reflecting "nighttime residential" distribution.
View Article and Find Full Text PDFBMJ Public Health
September 2025
School of Public Health, Nanjing Medical University, Nanjing, China.
Background: Since the emergence of the COVID-19 pandemic, how meteorological factors and COVID-19 control measures in China impact the transmission dynamics of influenza-like illness (ILI) across age groups remains unclear.
Objective: This study aims to explore the changes in the seasonal ILI epidemics and the effects of meteorological factors across age groups in Jiangsu, China, before the COVID-19 pandemic and after the relaxation of COVID-19 control measures.
Methods: The time-varying reproduction number ( ) and doubling time of ILI were deployed to describe the trend and iteration time of the ILI epidemic, and the effect of Chinese government response to COVID-19 on the ILI epidemic, respectively.
Front Pediatr
August 2025
Department of Pediatric Orthopedics, Children's Hospital of Nanjing Medical University, Nanjing, China.
Background: Isolated sustentaculum tali fractures among pediatric cohorts represent an exceedingly uncommon entity (<1% of all calcaneal fractures), with limited published evidence regarding operative intervention in prepubescent patients. Diagnostic complexities emerge from radiographically indiscernible fracture patterns, mandating cross-sectional imaging modalities. This case study documents the youngest reported patient (7-year-old female) and introduces the first comprehensive morphometric analysis of fracture characteristics and clinical outcomes following surgical management via open reduction and internal fixation (ORIF) utilizing Kirschner wire (K-wire) stabilization.
View Article and Find Full Text PDFFront Cell Dev Biol
August 2025
Department of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan, China.
Osteoarthritis (OA) is the most widespread joint disorder worldwide. It is a major cause of lower limb mobility issues in the elderly. With the ongoing aging of the global population and the increasing prevalence of obesity, the disease burden associated with OA is expected to rise significantly.
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