Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Early cervical lymph node (LN) metastasis is an important cause of poor survival in patients with medullary thyroid cancer (MTC). This study evaluated whether the preoperative serum calcitonin level in combination with ultrasonographic features of MTC can be used to assess the LN status as well as predict the risk of metastasis in patients with MTC.
Methods: We retrospectively analyzed the clinical data of 95 patients with MTC, and a nomogram model was constructed and validated. Using integrated database analysis of The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx), we mined pathways wherein is involved, identified calcitonin-related genes, and analyzed their functions.
Results: Correlation analysis revealed a significant association between the infiltrating range, diameter, calcification, blood flow, the preoperative serum calcitonin level, and metastasis. The metastasis risk-prediction model showed great accuracy in determining the risk of metastasis in MTC (area under the curve of the receiver operating characteristic [ROC] curve: 0.979 [95% confidence interval 0.946-1.000]). Decision curve analysis (DCA) showed that the model has excellent clinical utilization potential. Significantly, , the mRNA for calcitonin, was highly expressed in thyroid cancer tissues and associated with the cytokine-cytokine receptor and neuroactive ligand-receptor interaction pathways as well as the cell-adhesion molecules. ROC curve indicated that the , , , and genes, which are related to the cytokine-cytokine receptor interaction pathway, could indicate the risk of metastasis in MTC.
Conclusions: The preoperative serum calcitonin level, in combination with ultrasonographic features, can be used to predict the risk of metastasis in patients with MTC and constitute a noninvasive accurate method for preoperative diagnosis of MTC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906989 | PMC |
| http://dx.doi.org/10.1155/2022/9980185 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cystoscopic-Guided Laser Ablation of Intramural Ectopic Ureters in Male Dogs: A Retrospective Study of 18 Cases (2011-2023).
J Vet Intern Med
September 2025
Schwarzman Animal Medical Center, New York, New York, USA.
Background: There are limited studies on cystoscopic-guided laser ablation for treating ectopic ureters in male dogs. Further investigation is needed to assess its safety and efficacy.
Hypothesis/objective: Retrospectively describe long-term outcomes in male dogs treated using cystoscopic-guided laser ablation of ectopic ureters (CLA-EU).
Coagulation Disorders in Patients With Acute Respiratory Distress Syndrome Following Acute Aortic Dissection: A Prospective Observational Study.
Rev Cardiovasc Med
August 2025
Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Background: Coagulation disorders are potentially one of the most important pathogeneses of acute respiratory distress syndrome (ARDS) following acute type A aortic dissection (ATAAD). This study aimed to determine whether aortic dissection singularly and cardiopulmonary bypass (CPB) surgery can activate coagulation pathways, promoting ARDS development in patients with ATAAD.
Methods: A total of 450 patients who received treatment at Beijing Anzhen Hospital, Capital Medical University, between March 2023 and February 2024 were consecutively enrolled in this prospective cohort study.
Prognostic value of combined monitoring of serum S100A12 and optic nerve sheath diameter in patients with traumatic intracranial hematoma: a single-center prospective observational study.
Neurol Res
September 2025
Department of Neurosurgery, Xingtai Central Hospital, Xingtai, China.
Objective: To investigate the prognostic significance of concurrent monitoring of serum S100 calcium-binding protein A12 (S100A12) and optic nerve sheath diameter (ONSD) in patients with traumatic intracranial hematoma.
Methods: This prospective observational study included 198 patients with traumatic intracranial hematoma from Xingtai Central Hospital (February 2022-June 2024). Serum S100A12 and ONSD were measured at admission and postoperatively, and patients received minimally invasive therapy.
Prognostic Value of Perioperative Serum Creatinine Kinase Levels for Metachronous Colorectal Liver Metastasis.
Cureus
September 2025
Health Management Center, Japan Community Health Care Organization (JCHO) Funabashi Central Hospital, Chiba, JPN.
Background: Although decreased serum creatine kinase (s-CK) levels are observed in some cancers, possibly due to consumption during tumor growth, the relationship between s-CK levels and colorectal liver metastasis remains unclear. This study investigated the prognostic significance of perioperative s-CK levels in patients with metachronous colorectal liver metastasis.
Methods: A total of 46 patients who underwent liver resection from 2011 to 2023 were included in this study.
Patent ductus venosus is a congenital portosystemic shunt that may cause progressive portal hypertension, hepatic encephalopathy, and focal nodular hyperplasia of the liver. Embolization of the Arantius' duct is the first choice of treatment in infants and children. However, it carries the risk of coil migration into the systemic circulation in adult patients with larger Arantius ducts.
View Article and Find Full Text PDF