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http://dx.doi.org/10.1080/21507740.2022.2048721 | DOI Listing |
Clin Epigenetics
September 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Background: Work-related stress is a well-established contributor to mental health decline, particularly in the context of burnout, a state of prolonged exhaustion. Epigenetic clocks, which estimate biological age based on DNA methylation (DNAm) patterns, have been proposed as potential biomarkers of chronic stress and its impact on biological aging and health. However, their role in mediating the relationship between work-related stress, physiological stress markers, and burnout remains unclear.
View Article and Find Full Text PDFBMC Public Health
September 2025
Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden.
Background: As populations age, more knowledge is needed on people who extend their working lives. The aim of this study was to explore if prior sickness absence (> 14 days) and/or disability pension (SADP) in mental and/or somatic diagnoses were associated with time until work exit after ages 65-69 and ≥ 70, respectively, among women and men.
Methods: This prospective population-based cohort study included all 65-69-year-olds (cohort65, n = 201,263) and ≥ 70-year-olds (cohort70, n = 93,751) who were in paid work in Sweden in 2014.
Geroscience
September 2025
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
The aging population worldwide faces an increasing burden of age-related conditions, with Alzheimer's disease being a prominent neurodegenerative concern. Drug repurposing, the practice of identifying new therapeutic applications for existing drugs, offers a promising avenue for accelerated intervention. In this study, we utilized the yeast Saccharomyces cerevisiae to screen a library of 1760 FDA-approved compounds, both with and without rapamycin, to assess potential synergistic effects on yeast growth.
View Article and Find Full Text PDFCell Death Dis
September 2025
Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
In recent years, there has been a rapid increase in the incidence of thyroid carcinoma (TC). Our study focuses on the regulatory effect of circular RNAs on metabolism of TC, aiming to provide new insights into the mechanisms of progression and a potential therapeutic target for TC. In this study, we identified high expression levels of circPSD3 in TC tissues through RNA sequencing.
View Article and Find Full Text PDFInt J Food Microbiol
September 2025
College of Food Science, Southwest University, Chongqing 400715, PR China; Research Center for Fruits and Vegetables Logistics Preservation and Nutritional Quality Control, Southwest University, PR China; Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400715
Postharvest softening of Agaricus bisporus (A. bisporus) is a major factor in its quality deterioration. However, the physiological changes involved in softening of A.
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