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Article Abstract
An inulin (CPPF), isolated from a traditional Chinese herbal medicine , was characterized and demonstrated with potential prebiotic activity before. Based on its non-digested feature, the intestinal mucosa and microbiota modulatory effects on immunosuppressed mice were investigated after oral administration of 200, 100 and 50 mg/kg of CPPF for 7 days. It was demonstrated that the secretions of sIgA and mucin 2 (Muc2) in ileum were improved by CPPF, and the anti-inflammatory activities in different intestine parts were revealed. The intestine before colon could be the target active position of CPPF. As a potential prebiotic substance, a gut microbiota restorative effect was also presented by mainly modulating the relative abundance of , including , and Lachnospiraceae after high-throughput pyrosequencing of V4 region of 16S rRNA analysis. All these results indicated that this main bioactive ingredient inulin from was a medicinal prebiotic with enhancing mucosal immune, anti-inflammatory and microbiota modulatory activities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882912 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.786141 | DOI Listing |
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