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Article Abstract
Under the guidance of LC-MS/MS-based molecular networking, seven new verrucosidin derivatives, penicicellarusins A-G (-), were isolated together with three known analogues from the fungus . The structures of the new compounds were determined by a combination of NMR, mass and electronic circular dichroism spectral data analysis. The absolute configuration of penicyrone A () was corrected based on X-ray diffraction analyses. Bioactivity screening indicated that compounds , , and showed much stronger promising hypoglycemic activity than the positive drug (rosiglitazone) in the range of 25-100 μM, which represents a potential new class of hypoglycemic agents. Preliminary structure-activity relationship analysis indicates that the formation of epoxy ring on C-C in the structures is important for the glucose uptake-stimulating activity. The gene cluster for the biosynthesis of is identified by sequencing the genome of and similarity analysis with the gene cluster of verrucosidins in .
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| http://dx.doi.org/10.3390/jof8020143 | DOI Listing |
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