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A 62-year-old-woman with a suspected Tumor-induced-osteomalacia (TIO), a rare neoplastic syndrome that results in renal phosphate wasting with hypophosphatemia, underwent Ga-DOTATOC PET/CT on the suspicion of a mesenchymal tumor producing Fibroblast growth factor 23 (FGF23). Imaging revealed a small osteolytic, somatostatin receptor (SSTR) positive lesion containing calcifications in the alveolar process of the maxilla. No other SSTR-positive focus was found. A biopsy was performed by an oral and maxillofacial surgeon that revealed a calcifying epithelial odontogenic tumor (Pindborg tumor). This case shows that epithelial odontogenic tumors as an uncommon benign tumor entity can also be SSTR-positive.
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http://dx.doi.org/10.3390/diagnostics12020389 | DOI Listing |
Lab Invest
September 2025
Section of Pediatric Dentistry, Department of Oral Growth and Development, Fukuoka Dental College, Fukuoka, Japan; Oral Medicine Research Center, Fukuoka Dental College, Fukuoka, Japan.
Ameloblastoma (AM) is a benign epithelial odontogenic tumor that occurs in the jawbone. Although benign, AM can exhibit aggressive features, including locally invasive growth. Additionally, local recurrence or distant metastasis may occur.
View Article and Find Full Text PDFDent Med Probl
September 2025
The Children's Memorial Health Institute, Warsaw, Poland.
Background: Odontomas are odontogenic tumors located in the jawbone, referred to by the World Health Organization (WHO) as hamartomatous (Greek hamartion - a bodily defect) developmental malformations. The term was first used by Brock in 1866 to refer to every odontogenic tumor. Today an odontoma is believed to be a congenital malformation of dental hard tissues.
View Article and Find Full Text PDFArch Craniofac Surg
August 2025
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Background: Ameloblastoma is a benign odontogenic tumor that predominantly occurs in the mandible and is frequently associated with the BRAFV600E mutation, which activates the mitogen-activated protein kinase (MAPK) signaling pathway. These mutations indicate potential targets for molecular therapies. This systematic review evaluated the effectiveness of molecular-targeted therapies, particularly BRAF inhibitors such as dabrafenib and vemurafenib, in the treatment of ameloblastoma and their effects on clinical outcomes and quality of life.
View Article and Find Full Text PDFJ Dent (Shiraz)
September 2025
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Hybrid odontogenic lesions (HOLs) show combined microscopic features of two or more recognized odontogenic cysts and neoplasms, occurring in the same primary location. These lesions are uncommon and there is limited information on the clinical and microscopic features of such lesions.
Purpose: We aimed to assess the frequency and types of HOLs admitted to a main oral pathology center in Iran in 30 years.
Malays J Pathol
August 2025
Universiti Malaya, Faculty of Dentistry, Department of Oral and Maxillofacial Clinical Sciences, Malaysia.
Introduction: Ameloblastoma is a benign but locally aggressive odontogenic tumour broadly divided into conventional, unicystic, peripheral, adenoid and metastasising types. The first three entities compose the majority and especially the conventional type which has different histopathological subtypes such as follicular, plexiform, acanthomatous, granular cell, basal cell and desmoplastic have been described. We report the largest series of ameloblastoma in a single study to analyse the demographic characteristics according to histopathological subtypes of ameloblastoma.
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