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Computed tomography (CT) is a common modality for liver diagnosis, treatment, and follow-up process. Providing accurate liver segmentation using CT images is a crucial step towards those tasks. In this paper, we propose a stacked 2-U-Nets model with three different types of skip connections. The proposed connections work to recover the loss of high-level features on the convolutional path of the first U-Net due to the pooling and the loss of low-level features during the upsampling path of the first U-Net. The skip connections concatenate all the features that are generated at the same level from the previous paths to the inputs of the convolutional layers in both paths of the second U-Net in a densely connected manner. We implement two versions of the model with different number of filters at each level of each U-Net by maximising the Dice similarity between the predicted liver region and that of the ground truth. The proposed models were trained with 3Dircadb public dataset that were released for Sliver and 3D liver and tumour segmentation challenges during MICCAI 2007-2008 challenge. The experimental results show that the proposed model outperformed the original U-Net and 2-U-Nets variants, and is comparable to the state-of-the-art mU-Net, DC U-Net, and Cascaded UNET.
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http://dx.doi.org/10.1155/2022/8501828 | DOI Listing |
J Am Coll Surg
September 2025
Departments of Endocrine and General Surgery, Cleveland Clinic, Cleveland, OH.
Background: Although traditionally reserved for unresectable lesions, recent studies have provided evidence that in selected patients, microwave ablation (MWA) may provide similar oncologic outcomes compared to liver resection (LR). This study aimed to compare oncologic outcomes of patients with solitary small (<3 cm) colorectal liver metastasis (CRLM) undergoing LR vs laparoscopic MWA.
Study Design: This retrospective study included patients with a solitary CRLM <3cm treated with LR or MWA in three centers over 25-years.
J Ultrasound Med
September 2025
Department of Clinical Analysis, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.
Objectives: To evaluate the performance of artificial intelligence (AI)-based models in predicting elevated neonatal insulin levels through fetal hepatic echotexture analysis.
Methods: This diagnostic accuracy study analyzed ultrasound images of fetal livers from pregnancies between 37 and 42 weeks, including cases with and without gestational diabetes mellitus (GDM). Images were stored in Digital Imaging and Communications in Medicine (DICOM) format, annotated by experts, and converted to segmented masks after quality checks.
J Virol
September 2025
Division of Pediatric Infectious Disease, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Rift Valley fever virus (RVFV) causes mild to severe disease in livestock and humans. It was first identified in 1931 during an epizootic in Kenya and has spread across Africa and into the Middle East. Hematopoietic cells are one of the major targets of RVFV ; however, their contribution to RVFV pathogenesis remains poorly understood.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Department of Surgery, Tokushima University, Tokushima, Japan.
Background: Although magnification is an advantage of robotic liver resection (RLR) as it enables precise surgery, the direction of parenchymal dissection, the vascular anatomy, and the tumor location can sometimes be lost. Extended reality (XR) has advantages over other navigation systems in terms of spatial awareness, sharing, and simplicity, and it also has the potential to overcome some of the limitations of RLR. METHODS: In this video, we demonstrate innovative RLR with XR by three separate surgeons.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Carle Illinois College of Medicine University of Illinois Urbana-Champaign, 509 W University Ave, Urbana, IL, 61801, USA.
Background: The liver cone unit (Tokyo 2020 terminology) of the peripheral portal vein territory represents the smallest anatomical and functional unit of the liver. While this unit enables anatomical, subsegmental resection, particularly in patients with cirrhosis, the tumor-bearing cone unit can be challenging to identify intraoperatively. PATIENTS AND METHODS: A 58-year-old man with hepatitis C-related cirrhosis (Child-Pugh B) was diagnosed with a subcapsular hepatocellular carcinoma (HCC) in segment 8.
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