Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation.

J Invest Dermatol

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida, USA; Monasterium Laboratory, Münster, Germany; The Manchester Centre for Dermatology Research, Institute of Inflammation and Repair, University of Manchester, Mancheste

Published: September 2022


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2021.12.037DOI Listing

Publication Analysis

Top Keywords

mitochondrially localized
4
localized mpzl3
4
mpzl3 functions
4
functions negative
4
negative regulator
4
regulator sebaceous
4
sebaceous gland
4
gland size
4
size sebocyte
4
sebocyte proliferation
4

Similar Publications

Mitochondria continually undergo fission to maintain their network and health. Nascent fission sites are marked by the ER, which facilitates actin polymerization to drive calcium flux into the mitochondrion and constrict the inner mitochondrial membrane. Septins are a major eukaryotic cytoskeleton component that forms filaments that can both directly and indirectly modulate other cytoskeleton components, including actin.

View Article and Find Full Text PDF

Chronic intestinal pseudo-obstruction (CIPO) is a rare and severe intestinal motility disorder with poor long-term prognosis and high mortality rate, especially when the small intestine is involved. Due to the non-specificity of clinical symptoms, CIPO has long faced diagnostic challenges. With the advancements of sequencing technology, many hereditary CIPOs have been identified.

View Article and Find Full Text PDF

Camels have unique morphological traits that enable them to adapt well to harsh conditions. This work aims to describe the vascular architecture of the camel retina and investigate its cellular components with a focus on the distribution of mitochondria in Muller cells and photoreceptors, using light and electron microscopy. The camel retina is euangiotic in which blood vessels extend in the inner retina from the nerve fiber layer to the outer plexiform layer.

View Article and Find Full Text PDF

Aim: To investigate the functional significance of mitophagy in age-related osteogenic decline and the underlying mechanisms using in vivo and in vitro models.

Materials And Methods: An alveolar bone defect model in aged mice and a serial passaging-induced ageing model of human periodontal ligament stem cells (PDLSCs) were established. Osteogenic potential in mice was assessed by micro-CT, immunofluorescence, immunohistochemical analyses and histological staining.

View Article and Find Full Text PDF

Glutathione-responsive and mitochondria targeting enhanced photodynamic therapy and cascade-triggered carbon monoxide release for all-in-one tumor therapy.

J Colloid Interface Sci

September 2025

School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China; Henan International Joint Laboratory of Smart Molecules and Identification and Diagnostic Functions, Henan Normal University, Xinxiang, Henan 453007, China. Electronic address:

Carbon monoxide (CO) has demonstrated significant potential in tumor therapy. However, the uncontrolled release of CO and single-modality therapy often fail to achieve the desired therapeutic outcomes. To address the above deficiencies, mesoporous silica nanoparticles containing tetrasulfide bonds (TMSNs) were constructed as intelligent nanocarriers to co-deliver a mitochondria-targeting photosensitizer (Au-TPP) and a photodynamically activated CO-releasing molecule (FeCO), enabling the synergistic combination of photodynamic therapy (PDT) and CO therapy.

View Article and Find Full Text PDF