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Background And Aims: Alcohol demand, a measure of alcohol's reinforcing value, is associated with greater alcohol consumption and alcohol-related problems. Although alcohol demand has primarily been evaluated as a 'trait-like', individual difference measure, recent evidence indicates that demand exhibits meaningful short-term fluctuations. We aimed to determine whether moment-to-moment fluctuations in alcohol demand in individuals' natural drinking environments predicted drinking occurrence, drinking continuation, and drinking quantity.
Design: Observational study.
Setting: Individuals' natural drinking environments in Columbia, Missouri, USA.
Participants: Eighty-nine young adults (56% female; mean age = 24.8) participated from November 2018 to October 2020. Participants reported 14.5 drinking days [standard deviation (SD = 8.1)] and 4.1 drinks per occasion (SD = 2.5) during ecological momentary assessment (EMA).
Measurements: Participants completed the alcohol purchase task at baseline. Following this, participants reported on their alcohol demand (breakpoint, O , intensity) and drinking behavior during EMA at daily, timed prompts from 6 p.m. to 2 a.m. They provided breathalyzer samples using a BACtrack Mobile® Pro. Models tested concurrent and prospective (lagged) associations between alcohol demand and drinking occurrence and drinking continuation after drinking initiation. Additional models tested concurrent associations between demand and breath alcohol concentrations (BrACs).
Findings: Higher alcohol demand was associated with higher odds of drinking and continued drinking for all demand indices at the momentary [odds ratio (OR) = 1.27-1.56, ps ≤ 0.03] and day-level (OR = 2.14-3.39, ps < 0.001). Additionally, lagged demand predicted higher odds of drinking occurrence and continuation at the following prompt (OR = 1.32-1.53, ps ≤ 0.004). Higher alcohol demand was associated with higher BrACs at the momentary (bs = 0.0011-0.0026, ps ≤ 0.03) and day-level (bs = 0.0053-0.0062, ps < 0.001). At the person-level, findings varied depending on the demand measure.
Conclusions: Alcohol demand appears to be associated with both when and how much individuals drink in their natural drinking environments. Elevations in alcohol demand appear to be associated with increased likelihood of drinking and continuing to drink, and greater total alcohol consumption, both within and across drinking days.
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http://dx.doi.org/10.1111/add.15822 | DOI Listing |
Sci Total Environ
September 2025
Laboratoire Physico-Chimie des Matériaux, Substances Naturelles et Environnement, Faculty of Sciences and Techniques, Abdelmalek Essaâdi University, Tangier, Morocco.
Escalating concentrations of norfloxacin (NFX) in surface and wastewaters demand sustainable remediation strategies. In this study, dual-functional hydrochars were synthesized from argan nut shells (ArNS) via hydrothermal carbonization (HTC), with process conditions optimized by varying temperature (150-200 °C) and residence time (2-6 h). Among the materials, H1:5@150-4-prepared at 150 °C for 4 h with a biomass-to-water ratio of 1:5-exhibited the best performance, achieving a monolayer NFX adsorption capacity of 27.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:
Development of effective, safe, and degradable food packaging is essential to meet the demands of consumers and to ensure the continued growth of the food industry. In this study, superabsorbent bioactive aerogels based on cellulose and polyvinyl alcohol combined with the antibacterial bioactive extracts extracted from Portulaca oleracea were fabricated for the preservation of chilled meats. The main physicochemical and mechanical properties of the bioactive aerogels were characterized and evaluated.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Molecular Biology and Genetics, Faculty of Science, Koç University, Istanbul, Türkiye.
The increasing demand for efficient recombinant insulin production necessitates the development of scalable, high-yield, and cost-effective bioprocesses. In this study, we engineered a novel mini-proinsulin (nMPI) with enhanced expression properties by shortening the C-peptide and incorporating specific residue substitutions to eliminate the need for enzymatic cleavage. To optimize its production, we applied a hybrid approach combining microscale high-throughput cultivation using the BioLector microbioreactor and statistical modeling via response surface methodology (RSM).
View Article and Find Full Text PDFIntegr Med Res
March 2026
Institute of Safety and Effectiveness Evaluation for Korean Medicine, Kyung Hee University, Seoul, South Korea.
Background: The number of injured workers using Traditional Korean Medicine (KM) soared from 752 in 2013 to 10,273 in 2023, yet this trend remains underexplored. This cross-sectional study examined the frequency and factors linked to KM and Western Medicine (WM) use among injured workers.
Methods: Data from 6,985 participants in the 2018 and 2023 waves of the Panel Study of Workers' Compensation Insurance (PSWCI) were analyzed.
Curr Drug Deliv
August 2025
Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India.
Introduction: Burn wounds are painful injuries that demand immediate and effective management. Conventional wound care solutions often have limitations, such as discomfort during application or removal and potential damage to healing tissue. Therefore, developing novel wound dressings that support biological processes and promote wound healing is highly beneficial.
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