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We present a technique to swiftly change the contents of a small sample chamber using only a few times the chamber volume. Our design has no dead volume and functions as a manifold that minimizes mixing between consecutive liquids at one inlet. Thereby, it is ideal for minimizing sample consumption. In addition, our fluidic circuit works as an efficient bubble trap. These properties make our design an exciting alternative to standard solutions using multiple valves and junctions.
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http://dx.doi.org/10.1063/5.0058259 | DOI Listing |
Biosens Bioelectron
December 2025
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Electronic address:
Microfluidic devices with built-in microvalves hold particular promise for minimizing sample volume requirements while automating sample preparation workflows. Such devices have typically been implemented in polydimethyl siloxane (PDMS) using multi-layer soft lithography. Both the material and assembly process of devices present challenges for scalable manufacturing and limit utilization of microfluidic automation at the point of care.
View Article and Find Full Text PDFMaterials (Basel)
July 2025
College of Science, Jinling Institute of Technology, Nanjing 211169, China.
Helium (He) accumulation in tungsten-widely used as a plasma-facing material in fusion reactors-can lead to clustering, trap mutation, and eventual formation of helium bubbles, critically impacting material performance. To clarify the atomic-scale mechanisms governing this process, we conducted systematic molecular statics and molecular dynamics simulations across a wide range of vacancy cluster sizes (n = 1-27) and temperatures (500-2000 K). We identified the onset of trap mutation through abrupt increases in tungsten atomic displacement.
View Article and Find Full Text PDFLangmuir
July 2025
Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.
The generation and manipulation of microbubbles on surfaces have been much more ubiquitous than those in the bulk liquid. In this paper, we report the generation and trapping of microbubbles at the laser boundary in the bulk of water. In a plasmonic suspension, the light intensity-induced temperature gradient leads to a Marangoni flow that can trap the microbubble.
View Article and Find Full Text PDFLab Chip
July 2025
San Jose State University, San Jose, California, USA.
A new monolithic bubble trap has been developed with a unique, orientation-independent design. The bubble trap has a spherical cavity and a central partition with internal passages that eliminate air bubbles effectively for extended periods of time. Flow testing was performed in a closed-loop microfluidic system to demonstrate effectiveness and robustness of the bubble trap.
View Article and Find Full Text PDFTher Apher Dial
October 2025
Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Introduction: Regional citrate anticoagulation (RCA) is highly recommended as an anticoagulation method for intermittent hemodialysis (IHD) in patients at high bleeding risk. Few studies have investigated the effect of ionized calcium (iCa) concentration at different pipeline points on circuit clotting in RCA using calcium-containing dialysate.
Methods: This prospective study included 185 IHD sessions treated with a two-stage RCA protocol.