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Article Abstract
NDM-1-producing multidrug-resistant brings formidable clinical challenges. We report a nosocomial outbreak of carbapenem-resistant in China. Six strains collected in the same ward showed close phylogenetic relatedness, indicating clonal expansion. Illumina and MinION sequencing revealed that three isolates harbored a novel genomic island 1 carrying a gene (SGI1-1NDM), while three other isolates showed elevated carbapenem resistance and carried a similar SGI1 but with two gene copies (SGI1-2NDM). Four new single nucleotide mutations were present in the genomes of the two- -harboring isolates, indicating later emergence of the SGI1-2NDM structure. Passage experiments indicated that both SGI variants were stably persistent in this clone without copy number changes. This study characterizes two novel -harboring SGI1 variants in and provides a new insight into resistance gene copy number variation in bacteria.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792935 | PMC |
| http://dx.doi.org/10.3389/fmicb.2021.800938 | DOI Listing |
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