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3D printing provides new opportunities to create devices used during radiotherapy treatments, yet little is known about the effect process parameters play on the proposed devices. This study investigates the combined influence of infill pattern, infill density and print orientation on surface dose, as well as on the mechanical properties of 3D printed samples, identifying the optimal infill patterns for use in radiotherapy devices including immobilisation. Fused deposition modelling (FDM) was used to produce sixty samples in two orientations for surface dose measurement, utilising ten different infill patterns. Surface dose testing was performed using a Varian Trubeam linear accelerator with a 6 MV photon beam. A further one hundred and twenty tensile test samples, designed according to ASTM D638 type I standards, were evaluated using a 50 KN Instron 5969. On average, horizontally printed samples had a lower surface dose measurement compared to the vertically orientated samples, with the Stars infill pattern recording the lowest surface dose values in the horizontal orientation, while the Hilbert Curve recorded the lowest surface dose in the edge orientation. Tensile tests revealed the 3D Honeycomb infill pattern to have the highest ultimate tensile strength (UTS) in both horizontal and edge orientations. Overall, the Stars infill pattern exhibited the optimal balance of low surface dose and above average UTS. This study shows how infill patterns can significantly affect dosimetry and mechanical performance of 3D printed radiotherapy devices, and the data can be used by design engineers, clinicians and medical physicists to select the appropriate infill pattern, density and print orientation based on the functional requirements of a radiotherapy device.
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http://dx.doi.org/10.1088/2057-1976/abb981 | DOI Listing |
J Hazard Mater
August 2025
Radiochemistry Unit, Department of Chemistry, The University of Helsinki, Helsinki 00560, Finland. Electronic address:
Uranium dioxide (UO) particles can be released from mines, nuclear fuel manufacturing, reactor accidents, and weapons use. They pose inhalation risks, yet their behavior in the human lung remains poorly understood. This study investigates the long-term chemical alteration and dissolution of µm-sized UO particles in two model lung fluids: Simulated Lung Fluid (SLF) and Artificial Lysosomal Fluid (ALF), representing extracellular and intracellular lung environments, respectively.
View Article and Find Full Text PDFJ Environ Radioact
September 2025
Analytical Chemistry and Control Department, Hot Laboratories and Waste Management Center (HLWMC), Egyptian Atomic Energy Authority (EAEA), 13759, Cairo, Egypt.
The huge volume waste of the produced water (PW) associated with petroleum extraction poses significant hazards to the surrounded environment due to its complex composition and the presence of various hazardous pollutants, including organic, inorganic, biological contaminants, and natural occurring radioactive materials (NORM). This study was conducted to investigate the factors affecting the removal of the long-lived radium isotopes, i.e.
View Article and Find Full Text PDFJ Endocrinol Invest
September 2025
Department of Endocrinology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Purpose: Patients with primary adrenal insufficiency (PAI) require mineralocorticoid replacement therapy in addition to glucocorticoids. These therapies should be considered in combination because most glucocorticoids also possess mineralocorticoid activity. We aimed to investigate the relationship between fludrocortisone and hydrocortisone-equivalent dosing in patients with PAI.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China; Key Laboratory of Low Carbon Cold Chain for Agricultural Products, Ministry of Agriculture and Rural Affairs, Tianjin 300134, China. Electronic address: wzj
For purpose of overcoming the negative impact of high-dose phenols on meat quality, xanthan gum (XG), a natural anionic polysaccharide, was employed to prevent the undesirable interaction between myofibrillar protein (MP) and gallic acid (GA, 150 μmol/g) and ameliorate the gel and emulsification characteristics of MP. XG dose-dependently alleviated the structural damage of MP caused by GA and reduced protein aggregation, manifested as the decrease in surface hydrophobicity, turbidity and aggregate size (p < 0.05) and increase in α-helix content and intrinsic fluorescence.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. Electronic address:
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) sustains viral latency and drives oncogenesis in EBV-driven malignancies such as nasopharyngeal carcinoma and lymphomas. The dimerization of EBNA1 acts as an indispensable molecular switch governing EBV latency and oncogenesis. Disruption of EBNA1 dimerization is a promising strategy, but existing small-molecule inhibitors lack sufficient specificity.
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