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Introduction: Cannabis use disorder (CUD) is a growing public health concern, and is highly comorbid with negative affective conditions such as anxiety and depression. Late adolescence and early adulthood represents a time of rapid emotion regulation development, as well as the onset of anxiety, mood, and substance use disorders, especially CUD. Maladaptive cognitive, behavioral, and emotional responding to one's own negative affect (in an effort to eliminate it) is associated with substance use, and represents a novel treatment target to improve outcomes of treatment for substance misuse.
Method: After development of a manual for a novel intervention, Affect Management Treatment (AMT) for CUD, a pilot randomized clinical trial was conducted in 18-25 year-old participants with CUD to evaluate the impact of this approach on negative affect, constructs (e.g., distress intolerance) representing maladaptive reactivity to negative affect, and cannabis use. Participants (N = 52) received either 12 sessions of standard cognitive behavioral therapy (CBT) for CUD or 12 sessions of AMT and were assessed on measures of negative affect, reactivity to negative affect, cannabis use, and cannabis use problems at baseline, throughout treatment, post-treatment, and 6-mo follow-up.
Results: AMT outperformed CBT in reducing negative affect and reactivity to negative affect, and it had a significant impact on cannabis use and cannabis use problems. There were no statistically significant between-group differences on cannabis outcomes.
Conclusions: AMT offers a novel, successful approach to the treatment of CUD.
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http://dx.doi.org/10.1016/j.brat.2022.104032 | DOI Listing |
Braz J Biol
September 2025
Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Departamento de Engenharia Ambiental, São José dos Campos, SP, Brasil.
The present study carried out the first systematic review with meta-analysis on the effects of metals and temperature rise individually and their associations with terrestrial invertebrates. Initially, a systematic review of peer-reviewed articles was performed. Meta-analysis demonstrated that metals negatively affected the fitness of annelids, arthropods, and nematodes and positively affected physiological regulation in annelids.
View Article and Find Full Text PDFClin Orthop Relat Res
August 2025
Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY, USA.
Background: Choosing the appropriate implants for reconstruction in revision TKA is essential for long-term fixation. While cones and augments are routinely utilized to address tibial defects, the effect of augment location and size on the biomechanical stability of revision TKA constructs and the indications for the use of metaphyseal cones are not known.
Questions/purposes: Is the risk of cement-implant debonding of revision TKA constructs impacted by the thickness and location (medial versus bicompartmental) of tibial augments and the presence of metaphyseal cones during (1) a demanding daily activity like stair ascent and (2) torsional loads?
Methods: Under institutional review board approval, we developed patient-specific finite-element models of revision TKA from four patients (three males and one female, ages 50 to 80 years, BMI 27 to 37 kg/m2) who underwent two-stage revision and had a CT scan with no metal artifact after first-stage implant removal.
PLoS One
September 2025
School of Nursing, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Background: Pediatric surgical diseases are conditions that require surgery in children to save lives, prevent disability, or provide palliative care. Surgeries can be major or minor based on factors like severity, and complexity. Prolonged hospital stay could significantly affect the limited resources of the hospital, and further lead to post-operative complications, and poor surgical outcome.
View Article and Find Full Text PDFPLOS Glob Public Health
September 2025
School of American and Global Studies, South Dakota State University, Brookings, South Dakota, United States of America.
It is possible that the negative attitudes toward COVID-19 vaccination developed by some people, such as self-identified Republicans, might spill over toward other vaccines. We conducted a survey experiment to investigate if mentioning COVID-19 vaccine in messages encouraging seasonal flu vaccination will negatively affect people's attitudes toward receiving a flu vaccine. The experiment was embedded in a survey fielded in South Dakota in April 2024.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Parma 43125, Italy.
Typically, people perform actions in a valenced-positive or negative-way, depending on their attitudes or desires. These forms of action are named vitality forms (VFs). While it is well established that action goals are mediated by a parieto-frontal network, less is known about the processing of VFs.
View Article and Find Full Text PDF