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A multimeric MRI blood pool contrast agent based on the -borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized -borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement and .
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793076 | PMC |
http://dx.doi.org/10.1021/acsabm.1c00717 | DOI Listing |
Organometallics
August 2025
Department of Chemistry, Texas A&M University, College Station, Texas 77843-3255, United States.
Intramolecular Lewis adducts, especially those bearing a boron Lewis acid and a phosphine oxide Lewis base, have become attractive motifs for tunable luminescence properties in materials. However, intramolecular Lewis adducts with Ch-(IV)O moieties (Ch = chalcogen) as Lewis bases are under-represented in the field. Here, we describe the syntheses of two chalcogen boranes of general formula -(PhCh)-(BMes)-CH (Ch = S (), Se ()) and their conversions into the corresponding chalcogen-oxide boranes of general formula -(PhChO)-(BMes)-CH (Ch = S (), Se ()).
View Article and Find Full Text PDFEur J Med Chem
December 2025
Laboratory of Biomedical Chemistry, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114, Wrocław, Poland. Electronic address:
Since their initial synthesis by Hawthorne in the 1960s, inorganic metallacarboranes - most notably cobalt bis(dicarbollide), [CoSAN], have been considered chemically inert and harmless to eukaryotic cells. This reputation for inertness has supported their use in a wide range of biomedical applications, including as a boron source for boron neutron capture therapy, antifungal and Gram-positive antibacterial agents, and superchaotropic membrane carriers for impermeable biologically important molecules. In this study, we report a surprising twist: newly synthesized, iodinated and charge-compensated [CoSAN] derivatives with boron-nitrogen (-B-N-) bond show promising anticancer activity.
View Article and Find Full Text PDFBioorg Med Chem
November 2025
School of Life Science and Technology, Institute of Science Tokyo, 4259 Nagatsuta-cho Midori-ku, Yokohama 226-8501, Japan; Laboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, 4259 Nagatsuta-cho Midori-ku, Yokohama 226-8501, Japan. Electronic addre
We have achieved efficient synthesis of trisubstituted meta-carboranes and identified cluster of differentiation 28 (CD28) regulators from our established compound library of the carborane skeleton. CD28-mediated co-stimulation plays an important role in T cell immune responses and is regulated by protein-protein interactions, such as those involving growth factor receptor binding protein 2 (Grb2) and phosphoinositide 3-kinase (PI3K), via Src homology 2 (SH2) domains. Among the synthesized carboranes, compound 5o exhibited the most efficient T cell activation with minimal cytotoxicity.
View Article and Find Full Text PDFChem Sci
May 2025
Institute for Inorganic Chemistry, Julius-Maximilians-Universität Würzburg Am Hubland 97074 Würzburg Germany
We present the synthesis and isolation of the first main-group phosphathioethynolates, [LBH(SCP)] (L = SIMes, CAAC; SIMes = 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene, CAAC = 1-(2,6-diisopropylphenyl)-3,3,5,5-tetramethylpyrrolidin-2-ylidene), in which phosphathioethynolate coordination occurs exclusively through the sulfur atom, giving rise to a phosphaalkyne-type structural motif. This is reflected in the reactivity of the SIMes derivative towards organic azides and [(η-CH)CoCp] (Cp = CH), which mirrors the behavior of 1-adamantylphosphaalkyne, yielding triazaphospholes and a mixed cyclopentadienyl-(1,3-diphosphete) sandwich complex, respectively. Deviations from typical phosphaalkyne reactivity are observed in reactions with boron-containing heterocycles such as pentaphenylborole (PPB) and a carboranyl-substituted 9-borafluorene, which yield an unprecedented bicyclic structure and a zwitterionic spiro compound, respectively.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
June 2025
Institute for Inorganic Chemistry and Institute for Sustainable Chemistry & Catalysis with Boron, Julius-Maximilians-Universität Würzburg, 97074, Würzburg, Germany.
Reactions between Rosenthal's titanocene (CpTi) and decamethyltitanocene (Cp*Ti) synthons with various bis(alkynyl)boranes were investigated. A series of titanium-fused boracyclobutenes were obtained through the reaction of the Cp*Ti synthon with (MeSi)NB(CCR) or PhB(CCPh). This represents the first realization of approaching this structural motif via the rearrangement of bis(alkynyl)boranes within the coordination sphere of a d-block metal.
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