Amphiphilic DTPA Multimer Assembled on Icosahedral -Borane Motif as High-Performance MRI Blood Pool Contrast Agent.

ACS Appl Bio Mater

International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, Missouri 65212, United States.

Published: September 2021


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Article Abstract

A multimeric MRI blood pool contrast agent based on the -borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized -borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement and .

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793076PMC
http://dx.doi.org/10.1021/acsabm.1c00717DOI Listing

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