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http://dx.doi.org/10.3389/fmicb.2021.808595 | DOI Listing |
Int J Parasitol Drugs Drug Resist
August 2025
Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, 605014, India. Electronic address:
Antimalarial resistance is a primary challenge in the treatment of malaria. The ongoing search for novel drug sources remains a critical strategy for addressing this issue. This study evaluated the blood stage antiplasmodial and cytotoxic activities of the crude extract and fractions obtained from Lepidobotrys staudtii.
View Article and Find Full Text PDFAim: To compare the preventative effect of the new antiseptic olanexidine gluconate (OLG) with conventional antiseptics on surgical site infections (SSIs) in gastroenterological surgery.
Methods: A comprehensive electronic literature search was conducted through November 2024 to identify studies comparing the occurrence of SSIs between OLG and conventional antiseptics (Conv), including povidone-iodine (PI) or chlorhexidine gluconate (CHG), for incisional site disinfection. The primary outcomes were the occurrence of overall SSI and incisional SSI (including superficial and deep incisional SSI).
Semin Vasc Surg
September 2025
Division of Vascular and Endovascular Surgery, Department of Surgery, Northwell Health, Manhasset, NY; Zucker School of Medicine at Hofstra, Hempstead, NY. Electronic address:
Peripheral arterial disease (PAD) is a prevalent and debilitating condition in elderly patients, often leading to critical limb threatening ischemia (CLTI) and major amputations. While endovascular interventions are usually preferred for their lower perioperative risk, open surgical revascularization should also be considered due to its durability and superior patency in complex disease patterns. Age alone does not determine suitability for surgery; rather, candidacy hinges on frailty, functional status, comorbidities, and anatomical considerations.
View Article and Find Full Text PDFFront Neurol
August 2025
Nuffield Department of Clinical Neurosciences, Oxford University Centre For Integrative Neuroimaging, Oxford, United Kingdom.
Introduction: Amblyopia is a neurodevelopmental visual disorder treated with occlusion or pharmacological penalization of the dominant, non-amblyopic eye in early childhood. After early childhood, efficacy of occlusion therapy is limited due to a reduction in neuronal plasticity, and no mainstay clinical treatment is available. Selective serotonin reuptake inhibitors (SSRIs) have been hypothesized to enhance neuroplasticity in the adult brain, thereby facilitating improvements in amblyopia.
View Article and Find Full Text PDFVirology
September 2025
Department of Medicine, Democritus University of Thrace, Alexandroupolis, Evros, Greece.
Background: Dengue virus (DENV) is a major global health challenge, causing over 7.6 million reported cases in 2024. Neutralizing monoclonal antibodies (NmAbs) have emerged as promising therapeutics to address the limitations of vaccines and lack of antivirals, but their development is complicated by viral diversity, "breathing" dynamics, and antibody-dependent enhancement (ADE).
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