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http://dx.doi.org/10.1038/d41573-022-00003-7 | DOI Listing |
Nutr J
September 2025
Department of Geriatric, The First Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang, 110001, China.
Objective: This study analyzed data from the US population to examine how oral microbiome diversity and diet quality individually and synergistically affect frailty.
Methods: This study included 6,283 participants aged 20 years or older from the 2009-2010 and 2011-2012 NHANES cycles. A frailty index (FI) consisting of 36 items was developed, with items related to nutritional status excluded.
J Enzyme Inhib Med Chem
December 2025
School of Life Sciences, Jinggangshan University, Ji'an, China.
Current antithrombotic therapies face dual constraints of bleeding complications and monitoring requirements. Although natural hirudin provides targeted thrombin inhibition, its clinical adoption is hindered by sourcing limitations. This study developed a recombinant hirudin variant HMg (rHMg) with enhanced anticoagulant activity through genetic engineering and established cost-effective large-scale production methods.
View Article and Find Full Text PDFPurpose: This study aims to validate the usefulness of T10-pelvic angle (T10PA) in predicting pelvic tilt (PT) restoration, proximal junctional kyphosis (PJK) development, and clinical outcomes after adult spinal deformity (ASD) surgery.
Methods: This retrospective study included 213 ASD patients who underwent fusion from the lower thoracic spine (T9 or T10) to the pelvis. T10PA was measured on 6-week postoperative radiographs as the angle between the center of T10 and the hip center, and from the hip center to the midpoint of the S1 upper endplate.
EJNMMI Rep
September 2025
Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan.
Background: Because the myocardium thickness and blood flow of the right ventricular (RV) are lower than those of the left ventricle, it is challenging to perceive the RV myocardium in normal individuals. This study aimed to measure the myocardial perfusion in the RV (myocardial blood flow [MBF], myocardial flow reserve [MFR]) from 13N-ammonia PET images and investigate the associations between the MBF and MFR in patients with and without coronary artery disease (CAD) in the right coronary artery (RCA) region. A total 121 MBF and MFR were retrospectively measured from PET images by referring to the radioactivity and clinical blood flow values of the left ventricle.
View Article and Find Full Text PDFNihon Koshu Eisei Zasshi
September 2025
Graduate School of Nursing Science, St. Luke's International University.
Objectives This study aimed to determine how turnover intentions among public health nurses have changed following their coronavirus disease 2019 (COVID-19) response compared to 10 years ago, using propensity score matching.Methods As part of the Committee on Public Health Nursing's 2022/2023 activities, we conducted a repeated cross-sectional survey among public health nurses based on the Job Demands-Resources Model, a theoretical framework for turnover intentions. We collected cross-sectional observational data from periods before and after the COVID-19 outbreak.
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