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http://dx.doi.org/10.1007/s12350-021-02885-3 | DOI Listing |
Lung
September 2025
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Introduction: Lactate has emerged as a multifunctional signaling molecule regulating various physiological and pathological processes. Furthermore, lactylation, a newly identified posttranslational modification triggered by lactate accumulation, plays significant roles in human health and diseases. This study aims to investigate the roles of lactate/lactylation in respiratory diseases.
View Article and Find Full Text PDFNephrol Dial Transplant
September 2025
Department of Pediatrics, RWTH Aachen University Hospital, Aachen, Germany.
Adolescents and young adults with chronic kidney disease (CKD), particularly those with genetic kidney diseases, face unique challenges as they transition from pediatric to adult nephrology care. This period is marked not only by changes in healthcare providers but also by significant developmental, psychosocial, and medical complexities. In response, the ERA Working Group on Genes and Kidney and the ESPN Working Group on Inherited Kidney Diseases have collaborated to develop practical advice for healthcare professionals involved in transition care across Europe and beyond.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
September 2025
Department of Nephrology, Wuyi County First People's Hospital, Jinhua City, Zhejiang Province, People's Republic of China.
Purpose: Metabolic syndrome (MetS) is linked to adverse outcomes in chronic diseases, but its impact on acute kidney injury (AKI) in elderly critically ill patients remains unclear. This study aimed to evaluate the association between MetS and 90-day mortality in this population.
Patients And Methods: A retrospective analysis included 774 elderly patients (≥65 years) with AKI admitted to the ICU from January 2022 to December 2023.
J Pharm Policy Pract
September 2025
Department of Health Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Background: Hypertension is a major global risk factor for cardiovascular disease and mortality. In Greece, prevalence is about 40%, with many cases undiagnosed or poorly managed. While doctors remain central to diagnosis and treatment, community pharmacists, as accessible healthcare professionals, can support early detection and ongoing management.
View Article and Find Full Text PDFDrug Des Devel Ther
September 2025
Department of Anesthesiology, The Second People's Hospital of Guiyang, The Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang, People's Republic of China.
Background: Remimazolam tosilate, a novel ultra-short-acting benzodiazepine, demonstrates promising safety profiles in clinical settings. While both remimazolam tosilate and etomidate provide hemodynamic stability during anesthesia induction, limited research has directly compared their effects on electroencephalogram (EEG) burst suppression (periods of transient brain wave silence), a potential predictor of adverse neurological outcomes. This study aims to compare the incidence rate of EEG burst suppression (ESR) with remimazolam tosilate versus etomidate by reviewing the drug regimens used by different anesthesiologists in clinical practice.
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