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Transcatheter aortic valve implantation (TAVI) is an alternative to open heart surgery in the treatment of symptomatic aortic valve stenosis, which is often the treatment of choice in elderly and frail patients. It carries a risk of embolic complications in the whole cerebral vascular bed, which includes the retinal vasculature. The main objective was the evaluation of retinal emboli visible on optical coherence tomography angiography (OCTA) following TAVI. This is a prospective, single center, observational study enrolling consecutive patients over two years. Patients were assessed pre- and post-TAVI. Twenty-eight patients were included in the final analysis, 82.1% were male, median age was 79.5 (range 52-88), median BCVA was 82.5 letters (range 75-93). Eight patients (28.6%) presented new capillary dropout lesions in their post-TAVI OCTA scans. There was no statistically significant change in BCVA. Quantitative analysis of macular or peripapillary OCTA parameters did not show any statistically significant difference in pre- and post-intervention. In conclusion, capillary dropout lesions could frequently be found in patients after TAVI. Quantitative measurements of macular and peripapillary flow remained stable, possibly indicating effective ocular blood flow regulation within the range of left ventricular ejection fraction in our cohort.
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http://dx.doi.org/10.3390/diagnostics11122399 | DOI Listing |
Invest Ophthalmol Vis Sci
September 2025
Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Purpose: To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).
Methods: Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula.
Biomedicines
August 2025
Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115, USA.
: Retinal capillary dropout, characterized by acellular capillaries or "ghost vessels," is an early pathological sign of diabetic retinopathy (DR) that remains undetectable through standard clinical imaging techniques until visible morphological changes, such as microaneurysms or hemorrhages, occur. This study aims to develop a non-destructive artificial intelligence (AI)-based method using fluorescein angiography (FA) images to detect early-stage, silent retinal capillary dropout. We utilized 94 FA images and corresponding destructive retinal capillary density measurements obtained through retinal trypsin digestion from 51 Nile rats.
View Article and Find Full Text PDFIndian Dermatol Online J
August 2025
Department of Dermatology, Venereology and Leprosy, Goa Medical College, Bambolim, Goa, India.
Background: Cutaneous vasculitis involves active inflammation of blood vessels of all caliber, leading to widespread systemic involvement and morbidity. The data regarding the utility of nailfold capillaroscopy (NFC) in cutaneous vasculitis is sparse. Since NFC offers direct visualization of the affected system, the microvasculature, its role appears promising and can serve as a valuable diagnostic adjunct.
View Article and Find Full Text PDFAm J Ophthalmol Case Rep
September 2025
University of Cincinnati, Department of Ophthalmology, 5110 231 Albert Sabin Way, 5th Floor, Cincinnati, OH, 45267-0527, USA.
Purpose: To present a case of bilateral retinal thrombotic microangiopathy and tractional retinal detachments in a pediatric patient with typical hemolytic uremic syndrome (HUS) weeks after resolution of systemic complications.
Observations: A 23-month-old female with a history of typical HUS requiring treatment with temporary peritoneal dialysis and eculizumab transfusions presents three months later with bilateral fovea involving tractional retinal detachments. Sequential surgical repair of both eyes with pars plana vitrectomy was only successful in reattaching the superior retina of the right eye despite careful bimanual dissection.
Cureus
July 2025
Medicine, Universidad de Costa Rica, San José, CRI.
Optical coherence tomography angiography (OCTA) offers a promising approach for detecting subclinical microvascular changes in glaucoma suspects before structural or functional damage becomes apparent. This scoping review synthesizes evidence from 11 studies (2014-2025) to evaluate OCTA's effectiveness in identifying early glaucomatous alterations. Findings consistently demonstrate reduced vessel density (VD) in glaucoma suspects compared to healthy controls, with whole-image VD averaging 51.
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