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http://dx.doi.org/10.1016/j.xphs.2021.12.010 | DOI Listing |
Stroke
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT (L.H.S.).
Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials.
View Article and Find Full Text PDFAnal Chem
September 2025
Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria.
The discovery of solute precursors of crystalline materials, such as biominerals, recently challenged the classical nucleation theory (CNT). One emerging method for investigating these early-stage intermediates in solution is dissolution dynamic nuclear polarization (dDNP)-enhanced nuclear magnetic resonance (NMR) spectroscopy. Recent applications of dDNP to calcium carbonate (CaC) and calcium phosphate (CaP) mineralization have demonstrated the feasibility of identifying and tracing very early-stage prenucleation clusters (PNCs).
View Article and Find Full Text PDFJ Comput Chem
September 2025
Wilhelm-Ostwald-Institut für Physikalische und Theoretische Chemie, Leipzig University, Leipzig, Germany.
We investigated primary and secondary geometric isotope effects (H, D, T) on charge-inverted hydrogen bonds (CIHB) and dihydrogen bonds (DHB) using nuclear-electronic orbital density functional theory (NEO-DFT). The dianionic but electrophilic boron cluster [BH] served as a bonding partner, exhibiting a negatively polarized hydrogen atom in the BH bond. CIHB systems included interactions with Lewis acids (AlH, BH, GaH) and carbenes (CF, CCl, CBr), while DHBs were analyzed with NH, HF, HCl, and HBr.
View Article and Find Full Text PDFBiomed Chromatogr
October 2025
College of Food Science and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang, China.
To evaluate the quality of pomegranate peels from different cultivars, pomegranate peel samples from 47 cultivars were compared and classified based on fingerprints and chemical components obtained using HPLC-PDA-MS/MS combined with chemometric methods. Three pattern recognition methods, namely, hierarchical cluster analysis, principal component analysis, and partial least square-discriminant analysis, were used to establish classification models. Results showed that the contents of 10 components from pomegranate peel were determined.
View Article and Find Full Text PDFChembiochem
September 2025
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI), Beutenbergstrasse 11a, 07745, Jena, Germany.
Soils harbor some of the most diverse microbiomes on Earth. Interactions within these microbial communities are often mediated by natural products, many functioning as chemical signals. Specialized metabolites known as arginoketides, or arginine-derived polyketides, have been linked to mediate these interactions.
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