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Development of soft and conductive micro devices represents a demanding research topic in various biomedical applications, particularly organic bioelectronics. Among various fabrication methods, two-photon polymerization (2PP) using a wide range of photocurable inks is a promising 3D printing technique for construction of structures in submicron resolution. Herein, we introduce a novel conductive photosensitive resin by using poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) and poly(ethylene glycol) diacrylate), and fabricate 3D conductive polymeric microstructures via 2PP. In the developed resin, presence of PEDOT:PSS significantly enhances the electrical conductivity of microstructures (~ 10 orders of magnitude).Clinical Relevance- Conductive microdevices based on the PEDOT:PSS-doped resin open new avenues in a broad range of biomedical research areas including neural interfaces, biosensors, and bioelectronics.
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http://dx.doi.org/10.1109/EMBC46164.2021.9630885 | DOI Listing |
Eur J Med Chem
September 2025
State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address:
The Werner syndrome RecQ helicase (WRN) has recently emerged as a novel synthetic lethality target for microsatellite instability-high (MSI-H) cancers. However, available WRN inhibitors or degraders is still lacking so far. Particularly, chemically designed probes capable of degrading WRN irrespective of microsatellite status remain unexplored.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Materials Science and Engineering, College of Engineering, Texas A&M University, College Station, Texas 77843, United States.
Hydrogel-based bioinks are widely adopted in digital light processing (DLP) 3D printing. Modulating their mechanical properties is especially beneficial in biomedical applications, such as directing cell activity toward tissue regeneration and healing. However, in both monolithic and granular hydrogels, the tunability of mechanical properties is limited to parameters such as cross-linking or packing density.
View Article and Find Full Text PDFChem Rev
September 2025
Department of Physics, State Key Laboratory of Surface Physics, Fudan University, Shanghai 200438, P. R. China.
Diffusion is a fundamental process in the transfer of mass and energy. Diffusion metamaterials, a class of engineered materials with distinctive properties, enable precise control and manipulation of diffusion processes. Meanwhile, topology, a branch of mathematics, has attracted growing interest within the condensed matter physics community.
View Article and Find Full Text PDFPLoS One
September 2025
School of Computer Science, Georgia Institute of Technology, Atlanta, Georgia, United States of America.
Background: When analyzing cells in culture, assessing cell morphology (shape), confluency (density), and growth patterns are necessary for understanding cell health. These parameters are generally obtained by a skilled biologist inspecting light microscope images, but this can become very laborious for high-throughput applications. One way to speed up this process is by automating cell segmentation.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Understanding acute infectious disease dynamics at individual and population levels is critical for informing public health preparedness and response. Serological assays, which measure a range of biomarkers relating to humoral immunity, can provide a valuable window into immune responses generated by past infections and vaccinations. However, traditional methods for interpreting serological data, such as binary seropositivity and seroconversion thresholds, often rely on heuristics that fail to account for individual variability in antibody kinetics and timing of infection, potentially leading to biased estimates of infection rates and post-exposure immune responses.
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