Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol-also known as Propofol-a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel-Crafts alkylation followed by a decarboxylation step, both under continuous flow.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659244 | PMC |
| http://dx.doi.org/10.3390/molecules26237183 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being.
Front Allergy
August 2025
Department of Surgery, University of Auckland, Auckland, New Zealand.
Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are common respiratory conditions that significantly impact patient health and contribute to substantial healthcare burdens. While conventional treatments offer symptom relief, many patients continue to experience persistent symptoms, side effects, or resistance to standard therapies. This highlights the growing need for novel, non-invasive, and sustainable therapeutic strategies to manage chronic airway inflammation.
View Article and Find Full Text PDFSuccessful remission induction therapy with azacitidine and venetoclax for a treatment-naive elderly patient with ETP/myeloid mixed-phenotype acute leukemia: a case report.
Front Oncol
August 2025
Department Hematopathology, Shenzhen Hospital of Southern Medical University, Shenzhen, China.
Background: Mixed-phenotype acute leukemia (MPAL) is a rare acute leukemia for which data are currently not available to guide therapy. It has a poor outcome, particularly in elderly patients.
Case Presentation: We report the successful use of venetoclax/azacitidine as treatment for a treatment-naive elderly patient with early T-cell precursor (ETP)/myeloid MPAL.
Selective and green conversion of 5-HMF to FDCA enzymatic (laccase) and transition metal (MnO and Co-Mn/AC) catalysis in an integrated system.
RSC Adv
September 2025
Department of Chemical Engineering and Green Technology, Institute of Chemical Technology (ICT) Mumbai Maharashtra 400019 India
The sustainable synthesis of bio-based monomers from renewable biomass intermediates is a central goal in green chemistry and biorefinery innovation. This study introduces a synergistic catalytic-enzymatic strategy for the efficient and eco-friendly oxidation of 5-hydroxymethylfurfural (5-HMF) into 2,5-furandicarboxylic acid (FDCA), a key monomer for next-generation biodegradable plastics. The catalytic phase employed non-noble metal catalysts, MnO and Co-Mn supported on activated carbon (Co-Mn/AC), under mild batch reaction conditions at 90 °C.
View Article and Find Full Text PDFContinuous-flow-enabled intensification in nitration processes: a review of technological developments and practical applications over the past decade.
Beilstein J Org Chem
August 2025
China Construction Industrial & Energy Engineering Group Huanghe Construction Co., Ltd., 7 Yandong Xinlu, Lixia District, Jinan 250000, P. R. China.
Flow chemistry technology has demonstrated significant potential in advancing the green transformation of the chemical industry while enhancing inherent process safety. Safety, cost-effectiveness, and operational efficiency serve as pivotal drivers for advancing flow chemistry in nitration processes. This review provides a comprehensive analysis of the continuous-flow nitration technology - a process historically recognized as one of the most hazardous industrial operations - focusing on its technological advancements in process design, reaction kinetics characterization, and practical implementation over the past decade.
View Article and Find Full Text PDFAtomically Dispersed Palladium Promoted Suzuki-Miyaura Cross Coupling.
ChemSusChem
September 2025
Leibniz Institute for Catalysis e.V., Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
The palladium-catalyzed Suzuki-Miyaura cross coupling reaction to forge carbon-carbon bonds fundamentally changes the practice of organic synthesis. Herein an isolated palladium catalyst supported on polymeric carbon nitride (Pd/PCN) for efficient cross coupling of bromobenzene and phenylboronic acid at room temperature is reported. It is demonstrated that the Pd/PCN catalyst with a 2 wt% Pd loading achieves the highest mole-specific activity.
View Article and Find Full Text PDF