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Article Abstract
Objective: Determine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay) for Neuromyelitis Optica Spectrum Disorders (NMOSD).
Methods: We included Mayo Clinic patients (1/1/2018-12/31/2019) tested for serum AQP4-IgG by live cell-based flow-cytometric assay. Medical records were reviewed to assess if patients fulfilled 2015 NMOSD criteria.
Results: Of 1371 patients tested, 41 were positive (3%) and all fulfilled NMOSD criteria with AQP4-IgG (specificity = 100%). Only 10/1330 testing negative met NMOSD criteria without AQP4-IgG (sensitivity = 80%) and seven of these 10 were MOG-IgG positive.
Conclusions: AQP4-IgG by live cell-based assay was highly specific and without false positives in a high throughput setting.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637716 | PMC |
| http://dx.doi.org/10.1177/20552173211052656 | DOI Listing |
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