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Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes. Whether they are real has become the center of heated discussion where the main issues are their mechanism of assembly and function. A recent study describing these condensates as hubs for protein degradation by the ubiquitin system may shed a new light on this recent development in cell biology.
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http://dx.doi.org/10.1080/23723556.2021.1989939 | DOI Listing |
Chem Commun (Camb)
September 2025
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei 443002, China.
An unexpected additive-controlled chemodivergent multi-component domino reaction of salicylaldehydes with MBH carbonates has been skillfully developed. Interestingly, acid additives regulate the reaction to form functionalized cyclohexenes or natural coumarin derivatives. Notably, the coumarins were produced a novel phosphine-mediated α-umpolung/Wittig olefination/cycloaddition/lactonization/elimination cascade.
View Article and Find Full Text PDFRSC Adv
August 2025
State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University Wuhan Hubei 430079 China
A one-pot synthesis of the pyrazolo[3,4-]pyrrolo[3,4-]pyridin-6-one skeleton has been developed using aryl methyl ketones, 3-aminopyrazoles, and enaminamides as substrates. This method features metal-free catalysis and broad substrate compatibility (36 examples). The reaction involves the formation of two C-C and two C-N bonds, while constructing a tetrasubstituted carbon stereocenter bearing a reactive hydroxyl group.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Av. Ferrocarril San Rafael Atlixco 186, Col. Leyes de Reforma 1A Sección, Iztapalapa, Ciudad de México C.P. 09310, Mexico.
A one-pot synthetic methodology that combines an Ugi-Zhu three-component reaction (UZ-3CR) with a cascade sequence (intermolecular Diels-Alder cycloaddition/intramolecular -acylation/decarboxylation/dehydration) using microwave-heating conditions, ytterbium (III) triflate (Yb(OTf)) as the catalyst, and chlorobenzene (for the first time in a multi-component reaction (MCR)) as the solvent, was developed to synthesize twelve new fluorinated-pyrrolo[3,4-]pyridin-5-ones containing a 4-amino-7-chloroquinoline moiety, yielding 50-77% in 95 min per product, with associated atom economies around 88%, also per product. Additionally, by in vitro tests, compounds and were found to effectively stop early SARS-CoV-2 replication, IC = 6.74 µM and 5.
View Article and Find Full Text PDFJ Inflamm Res
July 2025
Department of Thyroid and Breast Diagnosis and Treatment Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan City, People's Republic of China.
Granulomatous lobular mastitis (GLM), a clinically challenging inflammatory breast disease, is characterized by a high recurrence rate, strong invasiveness, and a trend of affecting younger individuals, posing significant challenges to patients and clinical practitioners. Its pathological processes involve the abnormal activation of multiple signaling pathways, including NF-κB, NLRP3, JAK/STAT, TLR, MAPK, PI3K/AKT/mTOR, and Nrf2/HO-1. These pathways contribute to the disease's onset and progression by regulating inflammatory responses, immune reactions, and oxidative stress.
View Article and Find Full Text PDFJ Ethnopharmacol
July 2025
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address:
Ethnopharmacological Significance: Huanglian Zhimu decoction (HLZMD), a classical formulation in traditional Chinese medicine, has historically been utilized in the management of diabetes. However, its therapeutic efficacy and the underlying mechanisms in the context of T2DM, particularly in relation to hepatic lipid dysregulation, have yet to be systematically investigated.
Aim Of The Study: To explore the potential therapeutic effects and molecular mechanisms of HLZMD on T2DM.