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Aim: The present study was designed to explore the STR diversity and genomic history of the inhabitants of the most populous subdivision of the country. A set of 24 hypervariable autosomal STRs was used to estimate the genetic diversity within the studied population. A panel of 15 autosomal STRs, which is most common in the previously reported data sets, was used to estimate the genetic diversity between the studied population, and obtained unique relations were reported here.
Method: The genetic diversity and polymorphism among 636 individuals of different ethnic groups, residing in Bareilly, Pilibhit, Shahjahanpur, Gorakhpur, Jhansi, and Varanasi regions of Uttar Pradesh, India, was investigated. This investigation was carried out via 24 autosomal STRs.
Result: The 24 loci studied showed the highest value of combined power of discrimination (CPD = 1), combined power of exclusion (CPE = 0.99999999985), combined paternity index (CPI = 6.10 × 10) and lowest combined matching probability (CPM = 7.90 × 10).
Conclusion: The studied population showed genetic closeness with the population of Uttarakhand, the Jats of Delhi,the Jat Sikh (Punjab), and the population of Rajasthan. Among the tested loci, SE33 and Penta E were found to be most useful in terms of the highest discrimination power, lowest matching probability, the highest power of exclusion, and highest polymorphism information content for the Uttar Pradesh population .
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http://dx.doi.org/10.1080/03014460.2021.1995043 | DOI Listing |
Luminescence
September 2025
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
A triphenyl-imidazole end-capped donor-acceptor type potential molecular probe 3 has been designed and synthesized. Probe 3 upon interaction with different classes of metal ions/anions and NPPs displayed high selectivity with CN anion (LOD = 20.42 nM) through fluorescence "turn-Off" response and a naked-eye sensitive visible color change.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Saharanpur campus, Saharanpur, 247001, Uttar Pradesh, India. Electronic address:
In the modern era, polymyrcene, a sustainable polymer made from renewable resources, offers a potential path towards the advancement of green products. Here, we successfully created and characterized the first-ever all-bio-based composite films using cellulose nanocrystals (CNCs) made from agricultural waste, polylactic acid (PLA), and polymyrcene. Environmentally acceptable substitutes for traditional polymer composites have been made possible by incorporating CNCs into the PLA-Polymyrcene matrix, which produced materials with improved structural and functional qualities.
View Article and Find Full Text PDFVaccine
September 2025
Mérieux Foundation, 17 Rue Bourgelat, 69002 Lyon, France. Electronic address:
Introduction: Streptococcus pneumoniae is a major cause of lower respiratory infections, especially in children under 5 years old. While pneumococcal conjugate vaccines (PCVs) have reduced disease burden in many countries, data from low- and middle-income countries are still limited. The objective of this prospective, hospital-based, cross -sectional study was to measure the prevalence of pneumococcal colonization and identify circulating serotypes among children <5 years and their caregivers in Cambodia and India.
View Article and Find Full Text PDFJ Reprod Immunol
September 2025
Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India. Electronic address:
Pregnancy demands dynamic immune adaptations to support implantation, fetal growth, and labor while maintaining maternal-fetal tolerance. The immune profile shifts from pro-inflammatory during implantation to anti-inflammatory in mid-pregnancy, reverting to inflammation at labor onset. Key immune cells like NK cells, macrophages, dendritic cells, and T cells dominate the decidua, guiding successful placental development.
View Article and Find Full Text PDFJ Phys Chem B
September 2025
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India.
Understanding the evaporation mechanism of liquid ethanol and ethanol-water binary mixtures is important for numerous scientific and industrial processes. The amount of water in liquid water-ethanol mixtures can significantly affect how quickly ethanol molecules evaporate. Here, we study the mechanism and rate of evaporation of ethanol from pure liquid ethanol and ethanol/water binary mixtures through both unbiased molecular dynamics simulations and biased simulations using the umbrella sampling method.
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