Macrophage Switching in Pregnancy: Regulatory Mechanisms Governing Term Labour and Preterm Birth.

Macrophages play a pivotal role in the immune adaptations required for pregnancy, influencing both term and preterm labour (PTL) through their activation and polarisation. These immune cells originate from the yolk sac, foetal liver, and bone marrow, differentiating into diverse subtypes, including pro-inflammatory (M1) and anti-inflammatory (M2) macrophages. The dynamic transition between these states, termed macrophage switching, is crucial for maintaining pregnancy and orchestrating labour.

Computationally designed multi-epitope vaccine construct targeting the SARS-CoV-2 spike protein elicits robust immune responses in silico.

Our research is driven by the need to design an advanced multi-epitope vaccine construct (MEVC) using the S-protein of SARS-CoV-2 to combat the emergence of new variants. Through rigorous computational screening, we have identified linear and discontinuous B-cell epitopes, CD8 + and CD4 + T-cell epitopes, ensuring extensive MEVC coverage across 90.03% of the global population.

Impact of a Short Educational Session on Early Diagnosis and Management of Acute Kidney Injury for Different Specialties.

Aim And Objective: This questionnaire study aimed to evaluate the impact of a short educational session on the early diagnosis and management of acute kidney injury (AKI) among doctors specializing in fields other than nephrology, assessed through pre- and post-test scores. This educational study included resident doctors from various specialties for assessment.

Materials And Methods: The study enrolled different specialty resident doctors' departments and assessed them through questionnaires and assessment scores.

Paraspinal extramedullary hematopoiesis masquerading as nerve sheath tumor.

Paraspinal tumors are uncommon tumors involving the soft-tissue around the vertebrae. The lesion could originate from nerve roots, soft tissue, or blood vessels. The diversity of the lesions poses diagnostic dilemma, warranting robust histopathological diagnosis.

Recent Development of Heat and Mass Transport in the Presence of Hall, Ion Slip and Thermo Diffusion in Radiative Second Grade Material: Application of Micromachines.

This article describes the incompressible two-dimensional heat and mass transfer of an electrically conducting second-grade fluid flow in a porous medium with Hall and ion slip effects, diffusion thermal effects, and radiation absorption effects. It is assumed that the fluid is a gray, absorbing-emitting but non-scattering medium and the Rosseland approximation is used to describe the radiative heat flux in the energy equation. It is assumed that the liquid is opaque and absorbs and emits radiation in a manner that does not result in scattering.