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http://dx.doi.org/10.1186/s12943-021-01438-z | DOI Listing |
Clin Transl Oncol
September 2025
Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman, University, P.O.Box 84428, 11671, Riyadh, Saudi Arabia.
Esophageal cancer (EC) is one of the most serious health issues around the world, ranking seventh among the most lethal types of cancer and eleventh among the most common types of cancer worldwide. Traditional therapies-such as surgery, chemotherapy, and radiation therapy-often yield limited success, especially in the advanced stages of EC, prompting the pursuit of novel and more effective treatment strategies. Immunotherapy has emerged as a promising option; nonetheless, its clinical success is hindered by variable patient responses.
View Article and Find Full Text PDFJ Pain
September 2025
Clin(i)c of Urology, Pediatric Urology and Andrology, Justus-Liebig-University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen, Germany; Molecular Andrology, Justus-Liebig-University Giessen, Schubertstr. 81, 35392 Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Gi
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most prevalent urological condition in men under 50, characterized by persistent or recurrent pelvic and perineal pain, and significantly reduced quality of life. Reliable biomarkers for assessment and mechanistic understanding of pain remain limited. This retrospective case-control study consisting of 90 CP/CPPS patients (median age 29.
View Article and Find Full Text PDFJ Microbiol Immunol Infect
August 2025
Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, And College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:
Background: Third-generation cephalosporin-resistant Enterobacterales is a recognized global concern. This study investigated the molecular epidemiology of β-lactamase genes and antimicrobial susceptibility patterns among ceftriaxone-resistant Enterobacterales causing intra-abdominal and urinary tract infections in Taiwan between 2009 and 2019.
Methods: Data from the SMART surveillance program were analyzed, including Enterobacterales isolates with ceftriaxone minimum inhibitory concentrations ≥4 μg/mL.
Spectrochim Acta A Mol Biomol Spectrosc
September 2025
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, PR China; Department of Laboratory Medicine, School of Medicine, Yangtze University, Jingzhou 434023, PR China. Electronic address:
Hepatic carcinoma is one of the most common malignancies with low survival rates due to insufficient therapeutics while early detection of hepatic tumors remains key to reducing mortality of liver cancer. However, current clinical methods are hard to detect pathological changes in early-stage cases while the detection rate of liquid biopsy-based assay is limited. Thus, effective tools for accurate and sensitive detection of hepatic tumors are still in urgent need.
View Article and Find Full Text PDFBiologics
August 2025
Department of Internal Medicine, Section of Hematology and Medical Oncology, King Hussein Cancer Center, Amman, 11941, Jordan.
Purpose: Pancreatic cancer is one of the most lethal malignancies, with a five-year survival rate rarely exceeding 10%. Due to its asymptomatic onset, it is frequently diagnosed at an advanced and often inoperable stage. This review assesses current strategies for early detection, including genomic testing, advanced imaging technologies, and biomarker-based platforms, with a focus on their clinical utility and integration into surveillance protocols.
View Article and Find Full Text PDF