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Unlabelled: This study examined changes in the quality of life (QOL), as well as the factors affecting QOL, among patients with painful spinal bone metastases without paralysis for 1 month after radiotherapy.
Methods: This study included 79 participants (40 male and 39 female; median age, 65 (42-88) years) who had undergone radiotherapy for painful spinal bone metastases without paralysis. Patients' age, sex, activities of daily living (Barthel index), pain, spinal instability (spinal instability neoplastic score [SINS]), and QOL (EORTC QLQ-C30) were investigated.
Results: Having an unstable SINS score was a positive factor for global health status ( < 0.05). The improvement in activities of daily living and response to pain were positive factors for physical function ( < 0.05). A positive effect on emotional function was confirmed among female patients ( < 0.05).
Conclusion: Engaging in rehabilitation along with radiotherapy leads to improvements in QOL for patients with spinal bone metastases.
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http://dx.doi.org/10.3390/healthcare9111499 | DOI Listing |
Comput Methods Programs Biomed
August 2025
The Institute of Cancer Research, London, UK. Electronic address:
Background And Objective: Apparent Diffusion Coefficient (ADC) values and Total Diffusion Volume (TDV) from Whole-body diffusion-weighted MRI (WB-DWI) are recognised cancer imaging biomarkers. However, manual disease delineation for ADC and TDV measurements is unfeasible in clinical practice, demanding automation. As a first step, we propose an algorithm to generate fast and reproducible probability maps of the skeleton, adjacent internal organs (liver, spleen, urinary bladder, and kidneys), and spinal canal.
View Article and Find Full Text PDFLakartidningen
September 2025
-doktorand, ST--läkare, institutionen för -kirurgiska vetenskaper, Uppsala -universitet; VO ortopedi och handkirurgi, -Akademiska sjuk-huset, Uppsala.
Thoracic and lumbar fractures are common injuries that can be treated either surgically or non-surgically. This study investigated if socioeconomic and demographic factors influence treatment choices in Sweden using data from the Swedish Fracture Register and other national health registers. Results showed no significant association between socioeconomic factors and treatment choices.
View Article and Find Full Text PDFSpine (Phila Pa 1976)
October 2025
Niigata Spine Surgery Center, Kameda Daiichi Hospital, Niigata, Japan.
Study Design: Prospective cohort study.
Objective: To investigate longitudinal changes in physical functional status after long corrective fusion in patients with adult spinal deformity (ASD) during 2 years of follow-up.
Background: In ASD surgery, reports assessing physical functional status in long-term observations for more than a year are lacking.
Spine (Phila Pa 1976)
October 2025
Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, Philadelphia, PA.
Study Design: Retrospective cohort.
Objective: To evaluate the impact of having a history of obstructive sleep apnea (OSA) in patients undergoing anterior cervical discectomy and fusion (ACDF) on postoperative outcomes.
Background: With an aging population and rates of obesity increasing, comorbidities that influence patient safety are increasingly common.
Front Endocrinol (Lausanne)
September 2025
Department of Orthopedics I, Second Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China.
Background: Emerging evidence indicates that lactase-mediated histone lactylation can activate osteogenic gene expression and promote bone formation. However, the role of lactylation-related genes (LRGs) in osteoporosis (OP) remains unclear. This study aims to clarify the key roles of LRGs and the molecular mechanisms of related biomarkers in OP.
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