Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Damping of heartbeat-induced pressure pulsations occurs in large arteries such as the aorta and extends to the small arteries and microcirculation. Since recently, 7 T MRI enables investigation of damping in the small cerebral arteries.
Purpose: To investigate flow pulsatility damping between the first segment of the middle cerebral artery (M1) and the small perforating arteries using magnetic resonance imaging.
Study Type: Retrospective.
Subjects: Thirty-eight participants (45% female) aged above 50 without history of heart failure, carotid occlusive disease, or cognitive impairment.
Field Strength/sequence: 3 T gradient echo (GE) T1-weighted images, spin-echo fluid-attenuated inversion recovery images, GE two-dimensional (2D) phase-contrast, and GE cine steady-state free precession images were acquired. At 7 T, T1-weighted images, GE quantitative-flow, and GE 2D phase-contrast images were acquired.
Assessment: Velocity pulsatilities of the M1 and perforating arteries in the basal ganglia (BG) and semi-oval center (CSO) were measured. We used the damping index between the M1 and perforating arteries as a damping indicator (velocity pulsatility /velocity pulsatility ). Left ventricular stroke volume (LVSV), mean arterial pressure (MAP), pulse pressure (PP), and aortic pulse wave velocity (PWV) were correlated with velocity pulsatility in the M1 and in perforating arteries, and with the damping index of the CSO and BG.
Statistical Tests: Correlations of LVSV, MAP, PP, and PWV with velocity pulsatility in the M1 and small perforating arteries, and correlations with the damping indices were evaluated with linear regression analyses.
Results: PP and PWV were significantly positively correlated to M1 velocity pulsatility. PWV was significantly negatively correlated to CSO velocity pulsatility, and PP was unrelated to CSO velocity pulsatility (P = 0.28). PP and PWV were uncorrelated to BG velocity pulsatility (P = 0.25; P = 0.68). PWV and PP were significantly positively correlated with the CSO damping index.
Data Conclusion: Our study demonstrated a dynamic damping of velocity pulsatility between the M1 and small cerebral perforating arteries in relation to proximal stress.
Level Of Evidence: 4 TECHNICAL EFFICACY: Stage 1.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298760 | PMC |
| http://dx.doi.org/10.1002/jmri.27989 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations of cardiovascular health with arterial health in adults free of cardiovascular disease.
Am J Prev Cardiol
September 2025
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA.
Background: In adults without cardiovascular disease (CVD), there is limited understanding of the association between overall cardiovascular health (CVH) and arterial health.
Methods: In 2330 Framingham Heart Study Offspring participants free of CVD (60±9 years; 57% women) with Life's Essential 8 (LE8) and applanation tonometry data (Exam 7), we calculated CVH scores per American Heart Association's LE8 guidelines. Multivariable-adjusted regression analyses examined the relations of LE8 with aortic stiffness and pressure pulsatility [negative inverse carotid-femoral pulse wave velocity (niCFPWV), central pulse pressure (CPP), respectively], and examined effect modification by age and sex.
Prediction of Pre-Eclampsia at 18-24 Weeks of Gestation Using Maternal Ophthalmic Artery Doppler: A Prospective Observational Study From a Tertiary Care Centre in South India.
J Ultrasound Med
September 2025
Department of Fetal Medicine, The Fetal Clinic, Pondicherry, India.
Objectives: To determine the discriminatory capacity of maternal ophthalmic artery (OA) Doppler parameters at 18-24 weeks of gestation for predicting pre-eclampsia (PE) in a south Indian population and to compare its predictive ability with known markers of pre-eclampsia like mean arterial pressure (MAP) and uterine artery pulsatility index (UtA-PI).
Methods: This was a single-center prospective observational study of normotensive pregnant women presenting for routine ultrasound screening between 18 and 24 weeks of gestation. OA and UtA Doppler were performed on all enrolled participants who were followed up for subsequent development of PE.
Use of proper orthogonal decomposition and machine learning for efficient blood flow prediction in cerebral saccular aneurysms.
Sci Rep
September 2025
Department of Mechanical Engineering, College of Engineering, University of Ha'il, Ha'il City, 81451, Saudi Arabia.
Accurate assessment of intracranial aneurysm rupture risk, particularly in Middle Cerebral Artery (MCA) aneurysms, relies on a detailed understanding of patient-specific hemodynamic behavior. In this study, we present an integrated framework that combines Computational Fluid Dynamics (CFD) with Proper Orthogonal Decomposition (POD) and machine learning (ML) to efficiently model pulsatile blood flow using a Casson non-Newtonian fluid model, without incorporating fluid-structure interaction (FSI). Patient-specific vascular geometries were reconstructed from DICOM imaging data and simulated using ANSYS Fluent to capture key hemodynamic factors, including velocity components, pressure, wall shear stress (WSS), and oscillatory shear index (OSI).
View Article and Find Full Text PDFIn vitro characterization of hemodynamics in bicuspid aortic valves: The impact of valve and ascending aortic morphologies.
Magn Reson Med
September 2025
Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Purpose: This study investigated the effect of bicuspid aortic valve (BAV) morphology and ascending aortic curvature (AAAc) bending angles on aortic hemodynamics, focusing on transvalvular jets and secondary helical flows that contribute to systolic hemodynamic stress linked to aortic complications.
Methods: Using an MRI-compatible pulsatile flow and pressure system, 24 configurations involving six aortic valves (three Type 1 asymmetric BAVs, two Type 0 symmetric BAVs, and one tricuspid aortic valve [TAV]) across four ascending aortic morphologies-two diameters (30 mm and 40 mm) and two AAAc angles (130° and 109°)-were analyzed through four-dimensional-flow MRI measurements.
Results: Three Type 1 BAVs displayed highly deviated transvalvular jets directed toward the aortic wall on the side of the nonfused cusp.
Diabetes mellitus exacerbates cardiovascular remodeling in elderly Chinese by affecting aortic diameter and pulsatile load.
Sci Rep
September 2025
Department of Geriatrics, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, China.
Cardiovascular health is negatively impacted by arterial stiffening, which increases pulsatile load and elevates left ventricular workload. Aortic dilatation may compensate for the pulsatile overload resulting from arterial stiffening. Previous studies have shown a negative correlation between diabetes and aortic diameter, suggesting that diabetes may impair aortic dilatation and thereby compromise compensatory buffering capacity.
View Article and Find Full Text PDF