Prediction of Pre-Eclampsia at 18-24 Weeks of Gestation Using Maternal Ophthalmic Artery Doppler: A Prospective Observational Study From a Tertiary Care Centre in South India.

Objectives: To determine the discriminatory capacity of maternal ophthalmic artery (OA) Doppler parameters at 18-24 weeks of gestation for predicting pre-eclampsia (PE) in a south Indian population and to compare its predictive ability with known markers of pre-eclampsia like mean arterial pressure (MAP) and uterine artery pulsatility index (UtA-PI).

Methods: This was a single-center prospective observational study of normotensive pregnant women presenting for routine ultrasound screening between 18 and 24 weeks of gestation. OA and UtA Doppler were performed on all enrolled participants who were followed up for subsequent development of PE.

Correction: Optical, dielectric & ferroelectric studies on amino acids doped TGS single crystals.

[This corrects the article DOI: 10.1039/C5RA25700J.].

Correction: Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India.

[This corrects the article DOI: 10.1371/journal.pone.

Novel Benzimidazole-Endowed Chalcones as α-Glucosidase and α-Amylase Inhibitors: An Insight into Structural and Computational Studies.

In search of novel antidiabetic agents, we synthesized a new series of chalcones with benzimidazole scaffolds by an efficient 'one-pot' nitro reductive cyclization method and evaluated their α-glucosidase and α-amylase inhibition studies. The 'one-pot' nitro reductive cyclization method offered a simple route for the preparation of benzimidazoles with excellent yield and higher purity compared to the other conventional acid- or base-catalyzed cyclization methods. H, C NMR, IR, and mass spectrum data were used to characterize the compounds.

Biocatalytic enantioselective synthesis of cenobamate, an antiepileptic drug.

A green and efficient process for the synthesis of cenobamate has been accomplished in 70% yield and >99% ee through the bio-reduction of β-ketotetrazole using Daucus carota whole plant cells. The corresponding β-hydroxytetrazole was isolated in 60% yield and >98% ee. This is the first report on the biocatalytic reduction of β-ketotetrazole using plant enzymes derived from D.